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PGC protein :: Pepsinogen II Protein

Scan QR to view Datasheet Catalog #    MBS173574 PGC protein
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
1 mg  /  $860 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pepsinogen II (PGC), Protein

★Popular Item★
 Also Known As   

Pepsinogen II (PGII/PGC), Human Stomach

 Product Synonym Names    Pepsinogen C; PG II; PGC; Gastricsin; Pepsinogen II (PGII, PGC) - >=90% (SDS-PAGE) - Lyophilized
 Product Gene Name   

PGC protein

[Similar Products]
 Product Synonym Gene Name    RP11-298J23.1; PEPC; PGII [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    169740
 3D Structure    ModBase 3D Structure for P20142
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 Host    Human gastric mucosa
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 Purity/Purification    >= 90% (SDS-PAGE) may contain minor cleavage products.
 Form/Format    Powder, lyophilized from tris chloride, pH 8.5
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 Appearance    White to off-white powder.
 Solubility    Clear, colorless (1mg/mL 0.02 M Tris-Chloride, pH= 8.0 buffer)
 Protein    0.12 mg protein /vial (E 0.1%280nm= 1.43)
 Specific Activity    2,270 U/mg protein (after activation)
 Unit Definition    One unit will produce a change in A280 of 0.001 per minute at pH 2.0 and 37C, measured as TCA-soluble products from hemoglobin.
 Identity    Confirmed by Western Blot.
 Handling    Handle as a potentially hazardous substance
 Reconstitution    After reconstitution maintain at or above pH 8.0 to avoid activation.
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 Preparation and Storage    Store at -20C.
 Other Notes    Small volumes of PGC protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PGC protein

   MyBioSource is the leading producer and supplier of Human Pepsinogen II/C antigen as a stomach gastric cancer marker for medical research, clinical and diagnostic manufacturing.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human Pepsinogens are aspartic proteases produced in the gastric mucosa and secreted into the gastric lumen that play a major role in the digestion of porteins after activation of acidic pH. Pepsinogen is synthesized as isoymogens and are classified into two groups, I and II.
 Product Categories/Family for PGC protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Pepsinogen Ii (pgii; Pgc)
 Applications Tested/Suitable for PGC protein   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PGC. It may not necessarily be applicable to this product.
 NCBI GI #    129796
 NCBI GeneID    5225
 NCBI Accession #    P20142.1 [Other Products]
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 UniProt Primary Accession #    P20142 [Other Products]
 UniProt Secondary Accession #    Q5T3D7; Q5T3D8; B4DVZ3 [Other Products]
 UniProt Related Accession #    P20142 [Other Products]
 Molecular Weight    40,600
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 NCBI Official Full Name    Gastricsin
 NCBI Official Synonym Full Names    progastricsin (pepsinogen C)
 NCBI Official Symbol    PGC [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II
 UniProt Protein Name    Gastricsin
 UniProt Synonym Protein Names   
Pepsinogen C
 Protein Family    Gastricsin
 UniProt Gene Name    PGC [Similar Products]
 UniProt Entry Name    PEPC_HUMAN
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 NCBI Summary for PGC    This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
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 UniProt Comments for PGC    PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Protease; Secreted; EC

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: extracellular space

Molecular Function: aspartic-type endopeptidase activity

Biological Process: digestion; proteolysis
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 Research Articles on PGC    1. High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PGC proteinDiseases associated with PGC protein
 Reference Product  PubMed Publications
 PGD protein  >9 publications with PGC and PGD
 PCK1 protein  >8 publications with PGC and PCK1
 ESR1 protein  >1 publications with PGC and ESR1
 PCK2 protein  >1 publications with PGC and PCK2
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >265 publications with PGC and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >254 publications with PGC and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >236 publications with PGC and Disease Models, Animal
 Inflammation Antibodies  >200 publications with PGC and Inflammation
 Fatty Liver Antibodies  >185 publications with PGC and Fatty Liver
 Liver Diseases Antibodies  >147 publications with PGC and Liver Diseases
 Heart Diseases Antibodies  >147 publications with PGC and Heart Diseases
 Hypertrophy Antibodies  >113 publications with PGC and Hypertrophy
 Atrophy Antibodies  >108 publications with PGC and Atrophy
 Necrosis Antibodies  >107 publications with PGC and Necrosis
Organs/Tissues associated with PGC protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >525 publications with PGC and Liver
 Heart Antibodies  >357 publications with PGC and Heart
 Brain Antibodies  >289 publications with PGC and Brain
 Connective Tissue Antibodies  >224 publications with PGC and Connective Tissue
 Stomach Antibodies  >83 publications with PGC and Stomach
 Pancreas Antibodies  >54 publications with PGC and Pancreas
 Lung Antibodies  >44 publications with PGC and Lung
 Prostate Antibodies  >15 publications with PGC and Prostate
 Esophagus Antibodies  >4 publications with PGC and Esophagus
 Uncharacterized Tissue Antibodies  >1 publications with PGC and Uncharacterized Tissue
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