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PLG protein :: Plasminogen, Glu Protein

Scan QR to view Datasheet Catalog #    MBS635131 PLG protein
Unit / Price
1 mg  /  $410 +1 FREE 8GB USB
 
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 Product Name   

Plasminogen, Glu (PLG), Protein

 Also Known As   

Plasminogen, Glu, Human

 Product Gene Name   

PLG protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (161123225..161175086). Location: 6q26
 OMIM    173350
 3D Structure    ModBase 3D Structure for P00747
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 Host    Human plasma
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 Purity/Purification    Affinity Purified
Native glu-plasminogen is prepared from fresh frozen human plasma by a modification of the procedure of Castellino (3), utilizing gel filtration and affinity chromatography. The two carbohydrate variants of glu-plasminogen (CHOI and C
 Form/Format    Supplied as a liquid in 50% glycerol/H2O.
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 Extinction Coefficient    E1%1cm, 280nm=17.0 (5)
 Isoelectric Point    6.2 (1)
 Mode of Action    Zymogen; precursor to the serine protease plasmin
 Structure    Single chain, 24 intra chain disulfide bridges, 5 kringle regions.

Percent carbohydrate: ~2%
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of PLG protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PLG protein

   Plasminogen is a single chain glycoprotein zymogen which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4mM (1,2). The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These five triple-looped, three disulfide bridged, kringle regions are homologous to the kringle domains in t-PA, u-PA and prothrombin. Plasminogen contains one high affinity (Kd=9x10e-6M) and four low affinity (Kd=5x10e-3M) lysine binding sites. The high affinity binding site resides within the first kringle region of plasminogen. The interaction of plasminogen with fibrin and a2-antiplasmin is mediated by these lysine binding sites. Native glu-plasminogen (Mr=88,000) is readily converted to Lys-77-plasminogen (Mr=83,000) by plasmin hydrolysis of the Lys76-Lys77 peptide bond. Elastase catalyzed cleavage of the Val441-Val442 peptide bond of glu-plasminogen yields a functionally active zymogen termed Val-442 plasminogen or mini-plasminogen.

The conversion of plasminogen to plasmin occurs by a variety of mechanisms, but all result in hydrolysis of the Arg560-Val561 peptide bond of plasminogen, yielding two chains which remain covalently associated by a disulfide bond.
 Product Categories/Family for PLG protein    Molecular Biology; MB-Coagulation Factors
NCBI/Uniprot data below describe general gene information for PLG. It may not necessarily be applicable to this product.
 NCBI GI #    130316
 NCBI GeneID    5340
 NCBI Accession #    P00747.2 [Other Products]
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 UniProt Primary Accession #    P00747 [Other Products]
 UniProt Secondary Accession #    Q15146; Q5TEH4; Q6PA00 [Other Products]
 UniProt Related Accession #    P00747 [Other Products]
 Molecular Weight    88,000 [Similar Products]
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 NCBI Official Full Name    Plasminogen
 NCBI Official Synonym Full Names    plasminogen
 NCBI Official Symbol    PLG [Similar Products]
 NCBI Protein Information    plasminogen
 UniProt Protein Name    Plasminogen
 Protein Family    Plasminogen
 UniProt Gene Name    PLG [Similar Products]
 UniProt Entry Name    PLMN_HUMAN
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 NCBI Summary for PLG    The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
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 UniProt Comments for PLG    Plasminogen: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Defects in PLG are the cause of plasminogen deficiency (PLGD). PLGD is characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa. Belongs to the peptidase S1 family. Plasminogen subfamily.

Protein type: Protease; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; EC 3.4.21.7

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: extracellular space; cell surface; extrinsic to external side of plasma membrane; plasma membrane; extracellular region

Molecular Function: protein domain specific binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; apolipoprotein binding; receptor binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; tissue remodeling; muscle maintenance; myoblast differentiation; extracellular matrix disassembly; negative regulation of cell proliferation; fibrinolysis; negative regulation of fibrinolysis; cellular protein metabolic process; platelet degranulation; proteolysis involved in cellular protein catabolic process; tissue regeneration; positive regulation of fibrinolysis; blood coagulation; transmembrane transport

Disease: Plasminogen Deficiency, Type I
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 Research Articles on PLG    1. These findings highlight a critical role for plasmin in the catabolism of aggregated LDL by macrophages and provide a new context for considering the atherogenic role of plasmin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLG proteinPathways associated with PLG protein
 Reference Product  PubMed Publications
 SERPINE1 protein  >43 publications with PLG and SERPINE1
 PLAUR protein  >14 publications with PLG and PLAUR
 MMP9 protein  >5 publications with PLG and MMP9
 MMP3 protein  >2 publications with PLG and MMP3
 SPARC protein  >1 publications with PLG and SPARC
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with PLG proteinOrgans/Tissues associated with PLG protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >104 publications with PLG and Cardiovascular Diseases
 Thrombosis Antibodies  >86 publications with PLG and Thrombosis
 Nervous System Diseases Antibodies  >82 publications with PLG and Nervous System Diseases
 Brain Diseases Antibodies  >55 publications with PLG and Brain Diseases
 Inflammation Antibodies  >45 publications with PLG and Inflammation
 Liver Diseases Antibodies  >37 publications with PLG and Liver Diseases
 Blood Coagulation Disorders Antibodies  >31 publications with PLG and Blood Coagulation Disorders
 Hemorrhage Antibodies  >23 publications with PLG and Hemorrhage
 Venous Thrombosis Antibodies  >20 publications with PLG and Venous Thrombosis
 Necrosis Antibodies  >19 publications with PLG and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >397 publications with PLG and Blood
 Brain Antibodies  >114 publications with PLG and Brain
 Liver Antibodies  >76 publications with PLG and Liver
 Lung Antibodies  >41 publications with PLG and Lung
 Spleen Antibodies  >26 publications with PLG and Spleen
 Heart Antibodies  >22 publications with PLG and Heart
 Embryonic Tissue Antibodies  >20 publications with PLG and Embryonic Tissue
 Kidney Antibodies  >20 publications with PLG and Kidney
 Pancreas Antibodies  >4 publications with PLG and Pancreas
 Mammary Gland Antibodies  >4 publications with PLG and Mammary Gland
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