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ACPP protein :: Prostatic Acid Phosphatase Protein

Scan QR to view Datasheet Catalog #    MBS173168 ACPP protein
Unit / Price
100 Units  /  $140 +1 FREE 8GB USB
1000 Units  /  $290 +1 FREE 8GB USB
5000 Units  /  $995 +1 FREE 8GB USB
 
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 Product Name   

Prostatic Acid Phosphatase (ACPP), Protein

★Popular Item★
 Also Known As   

Prostatic Acid Phosphatase (PAP/ACP), Human

 Product Synonym Names    ACP; PAP; Acid Phos; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; Thiamine monophosphatase; TMPase; PAPf39; Prostatic Acid Phosphatase (ACP, PAP), Human Semen - Lyophilized
 Product Gene Name   

ACPP protein

[Similar Products]
 Product Synonym Gene Name    5'-NT; ACP-3; ACP3; PAP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 200950
 3D Structure    ModBase 3D Structure for P11117
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 Purity/Purification    Partially Purified
 Form/Format    Lyophilized
Appearance: Off-white powder
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 Source    Human Semen
 EC Number    3.1.3.2
 Unit Definition    One unit will catalyze the hydrolysis of one micromole of thymolphthalein monophosphate to thymolphthalein and phosphate per minute at pH 5.6 and 37 degree C.
 Specific Activity    Typically >= 30 U/mg protein
 Solubility    Clear, colorless solution (10 mg/mL saline)
 Recertification    3 years
 Protein    >= 0.2 protein/mg (Coomassie/Biuret)
 CAS Number    9001-77-8
 Activity    5 - 15 U/mg solid (Dimension Clinical Chemistry System)
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of ACPP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACPP protein

   MyBioSource produces human Prostatic Acid Phosphatase (PAP/ACP) for research,life science and diagnostic manufacturing uses.

Custom preparations, technical support, bulk quantities and aliquoting available.

What is Human Acid Phosphatase? Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP,ACP) is alternative marker to Prostate Specific Antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.

The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.

Human Prostate Acid Phosphatase also known as human prostatic acid phosphatase (PAP, ACP) is alternative marker to prostate specific antigen (PSA) for prostate malignancy. Rape investigations will often include testing for the presence of Human prostatic (prostate) acid phosphatase in vaginal fluid.

Human prostatic Acid phosphatase (PAP) is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore,Human Acid Phosphatase has an acid pH optimum below 7.0.
 Product Categories/Family for ACPP protein    Proteins; Antigens; Enzymes; Standards/controls; Native Proteins; Prostatic Acid Phosphatase (acp/pap)
NCBI/Uniprot data below describe general gene information for ACPP. It may not necessarily be applicable to this product.
 NCBI GI #    1199524
 NCBI GeneID    53
 NCBI Accession #    CAA33542.1 [Other Products]
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 UniProt Primary Accession #    P11117 [Other Products]
 UniProt Secondary Accession #    Q561W5; Q9BTU7; E9PCI1 [Other Products]
 UniProt Related Accession #    P11117 [Other Products]
 Molecular Weight    ~100,000
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 NCBI Official Full Name    acid phosphatase
 NCBI Official Synonym Full Names    acid phosphatase 2, lysosomal
 NCBI Official Symbol    ACP2 [Similar Products]
 NCBI Official Synonym Symbols   
LAP
[Similar Products]
 NCBI Protein Information    lysosomal acid phosphatase
 UniProt Protein Name    Lysosomal acid phosphatase
 Protein Family    Prostatic acid phosphatase
 UniProt Gene Name    ACP2 [Similar Products]
 UniProt Synonym Gene Names    LAP [Similar Products]
 UniProt Entry Name    PPAL_HUMAN
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 NCBI Summary for ACPP    This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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 UniProt Comments for ACPP    ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family.

Protein type: EC 3.1.3.2; Motility/polarity/chemotaxis; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - riboflavin; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2|11p12-p11

Cellular Component: lysosomal lumen; membrane; lysosomal membrane; lysosome; integral to membrane

Molecular Function: acid phosphatase activity

Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development

Disease: Acid Phosphatase Deficiency
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 Research Articles on ACPP    1. An enzymatically inactive allele of mouse Acp2 causes cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACPP proteinPathways associated with ACPP protein
 Reference Product  PubMed Publications
 ACP1 protein  >23 publications with ACPP and ACP1
 LDHA protein  >6 publications with ACPP and LDHA
 CTSD protein  >1 publications with ACPP and CTSD
 ACP5 protein  >1 publications with ACPP and ACP5
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Riboflavin Metabolism Pathway antibodies  Riboflavin Metabolism Pathway Diagram
 Riboflavin Metabolism Pathway antibodies  Riboflavin Metabolism Pathway Diagram
Diseases associated with ACPP proteinOrgans/Tissues associated with ACPP protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with ACPP and Nervous System Diseases
 Adenocarcinoma Antibodies  >1 publications with ACPP and Adenocarcinoma
 Aneuploidy Antibodies  >1 publications with ACPP and Aneuploidy
 Chromosome Aberrations Antibodies  >1 publications with ACPP and Chromosome Aberrations
 Liver Neoplasms Antibodies  >1 publications with ACPP and Liver Neoplasms
 Liver Neoplasms, Experimental Antibodies  >1 publications with ACPP and Liver Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with ACPP and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with ACPP and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with ACPP and Liver
 Blood Antibodies  >8 publications with ACPP and Blood
 Brain Antibodies  >6 publications with ACPP and Brain
 Spleen Antibodies  >2 publications with ACPP and Spleen
 Bone Marrow Antibodies  >2 publications with ACPP and Bone Marrow
 Bone Antibodies  >2 publications with ACPP and Bone
 Muscle Antibodies  >2 publications with ACPP and Muscle
 Skin Antibodies  >2 publications with ACPP and Skin
 Placenta Antibodies  >1 publications with ACPP and Placenta
 Prostate Antibodies  >1 publications with ACPP and Prostate
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