Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Protein rightarrow PROC  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • A kinase (PRKA) anchor protein 3 (AKAP9) Antibody
 • H5N1-HA1 Antibody
 • Tumor Necrosis Factor Receptor Type (TNFR) Recombinant Protein
 • NPL Antibody
 • G protein-coupled receptor 172A (GPR172A) ELISA Kit
 • ACE2 Antibody
 • AKT1 Antibody
 • Interferon Gamma (IFNg) ELISA Kit
 • Protein-lysine 6-oxidase (LOX) Recombinant Protein
 • Kit ligand protein (Kitlg) Recombinant Protein
 • Noggin (NOG) ELISA Kit
 • involucrin (IVL) ELISA Kit
 • Factor IX (F9) Antibody
 • luteinizing hormone (LH) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PROC protein :: Protein C Protein

Scan QR to view Datasheet Catalog #    MBS844024 PROC protein
Unit / Price
0.05 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein C (PROC), Protein

 Also Known As   

Protein C, Human Plasma

 Product Synonym Names    Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; PROC; PC; APC; PROC1; THPH3; THPH4.
 Product Gene Name   

PROC protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    176860
 3D Structure    ModBase 3D Structure for P04070
Section Bar
 Host    Human Plasma
Section Bar
 Purity/Purification    >=95%
 Form/Format    In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine -pH 7.4
Appearance: Liquid
Section Bar
 Handling    Centrifuge the vial prior to opening.
Section Bar
 Preparation and Storage    At -80 degree C
Shelf Life: 12 months
 Other Notes    Small volumes of PROC protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for PROC protein

   Background: Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.
 Product Categories/Family for PROC protein    Proteins and Enzymes; Native ProteinsProteins and Enzymes; Proteins and Enzymes (A-Z)
 Applications Tested/Suitable for PROC protein   

SDS-PAGE

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PROC. It may not necessarily be applicable to this product.
 NCBI GI #    4506115
 NCBI GeneID    5624
 NCBI Accession #    NP_000303.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000312.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P04070 [Other Products]
 UniProt Secondary Accession #    Q15189; Q15190; Q16001; Q53S74; Q9UC55; B4DPQ7 [Other Products]
 UniProt Related Accession #    P04070 [Other Products]
 Molecular Weight    62 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    vitamin K-dependent protein C preproprotein
 NCBI Official Synonym Full Names    protein C (inactivator of coagulation factors Va and VIIIa)
 NCBI Official Symbol    PROC [Similar Products]
 NCBI Official Synonym Symbols   
PC; APC; PROC1; THPH3; THPH4
[Similar Products]
 NCBI Protein Information    vitamin K-dependent protein C
 UniProt Protein Name    Vitamin K-dependent protein C
 UniProt Synonym Protein Names   
Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV
 Protein Family    Protein
 UniProt Gene Name    PROC [Similar Products]
 UniProt Entry Name    PROC_HUMAN
Section Bar
 NCBI Summary for PROC    This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
Section Bar
 UniProt Comments for PROC    PROC: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. Belongs to the peptidase S1 family.

Protein type: Apoptosis; Protease; EC 3.4.21.69

Chromosomal Location of Human Ortholog: 2q13-q14

Cellular Component: endoplasmic reticulum lumen; Golgi lumen; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; negative regulation of blood coagulation; post-translational protein modification; proteolysis; blood coagulation; peptidyl-glutamic acid carboxylation; leukocyte migration; negative regulation of apoptosis

Disease: Thrombophilia Due To Protein C Deficiency, Autosomal Recessive; Thrombophilia Due To Protein C Deficiency, Autosomal Dominant
Table BarTOPTable Bar
 Research Articles on PROC    1. Heterozygous F139V mutations caused mild reduction of protein C function, which might be the reason for survival of compound heterozygous or homozygous protein C deficiency adults carrying these mutations.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Diseases associated with PROC proteinOrgans/Tissues associated with PROC protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >13389 publications with PROC and Cardiovascular Diseases
 Kidney Diseases Antibodies  >7604 publications with PROC and Kidney Diseases
 Liver Diseases Antibodies  >6200 publications with PROC and Liver Diseases
 Heart Diseases Antibodies  >5901 publications with PROC and Heart Diseases
 Inflammation Antibodies  >4214 publications with PROC and Inflammation
 Necrosis Antibodies  >3222 publications with PROC and Necrosis
 Hypertension Antibodies  >3201 publications with PROC and Hypertension
 Pain Antibodies  >2524 publications with PROC and Pain
 Cell Transformation, Neoplastic Antibodies  >2472 publications with PROC and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1931 publications with PROC and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >24599 publications with PROC and Kidney
 Brain Antibodies  >22396 publications with PROC and Brain
 Liver Antibodies  >19832 publications with PROC and Liver
 Lung Antibodies  >7023 publications with PROC and Lung
 Spleen Antibodies  >4108 publications with PROC and Spleen
 Connective Tissue Antibodies  >3301 publications with PROC and Connective Tissue
 Uterus Antibodies  >1336 publications with PROC and Uterus
 Testis Antibodies  >1269 publications with PROC and Testis
 Mammary Gland Antibodies  >530 publications with PROC and Mammary Gland
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions