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AGP7 protein :: Proteinase 3 (PR3) Protein

Scan QR to view Datasheet Catalog #    MBS844097
Testing Data
Unit / Price
0.025 mg  /  $350 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proteinase 3 (PR3) (AGP7), Protein

★Popular Item★
 Also Known As   

Proteinase 3 (PR3), Human Neutrophil

 Product Synonym Names    AGP7; C-ANCA antigen; Leukocyte proteinase 3; Neutrophil proteinase 4; P29; Wegener autoantigen
 Product Gene Name   

AGP7 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    177020
 3D Structure    ModBase 3D Structure for P24158
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 Host    Human Neutrophils
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 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl
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 Host Note    Human Neutrophil. Prepared from whole blood shown to be non reactive for HBsAg, anti HCV, anti HBc, and negative for anti HIV 1 & 2 by FDA approved tests.
 Extinction Coefficient    1.00
 Handling    Centrifuge the vial prior to opening.
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 Preparation and Storage    Aliquot and store at - 70C or lower. Avoid repated freezing and thawing cycles.

Shipping: Dry Ice
 Other Notes    Small volumes of AGP7 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AGP7 protein

   Background: Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
 Product Categories/Family for AGP7 protein    Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteases; Other (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)
 Applications Tested/Suitable for AGP7 protein   


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 Testing Data of AGP7 protein    AGP7 protein Testing Data image
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NCBI/Uniprot data below describe general gene information for AGP7. It may not necessarily be applicable to this product.
 NCBI GI #    71361688
 NCBI GeneID    5657
 NCBI Accession #    NP_002768.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002777.3 [Other Products]
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 UniProt Primary Accession #    P24158 [Other Products]
 UniProt Secondary Accession #    P15637; P18078; Q4VB08; Q4VB09; Q6LBM7; Q6LBN2; Q9UD25; Q9UQD8 [Other Products]
 UniProt Related Accession #    P24158 [Other Products]
 Molecular Weight    29 kDa
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 NCBI Official Full Name    myeloblastin
 NCBI Official Synonym Full Names    proteinase 3
 NCBI Official Symbol    PRTN3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    myeloblastin
 UniProt Protein Name    Myeloblastin
 UniProt Synonym Protein Names   
AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
 Protein Family    Classical arabinogalactan protein
 UniProt Gene Name    PRTN3 [Similar Products]
 UniProt Synonym Gene Names    MBN; PR-3; PR3; NP-4 [Similar Products]
 UniProt Entry Name    PRTN3_HUMAN
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 UniProt Comments for AGP7    PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: EC; Protease; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol

Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis
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 Research Articles on AGP7    1. Anti-PR3 autoantibodies not detected in sera of patients with pulmonary tuberculosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGP7 proteinPathways associated with AGP7 protein
 Reference Product  PubMed Publications
 MYB protein  >1 publications with AGP7 and MYB
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with AGP7 proteinOrgans/Tissues associated with AGP7 protein
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >7 publications with AGP7 and Vascular Diseases
 Granulomatosis with Polyangiitis Antibodies  >7 publications with AGP7 and Granulomatosis with Polyangiitis
 Lung Diseases Antibodies  >5 publications with AGP7 and Lung Diseases
 Neural Tube Defects Antibodies  >1 publications with AGP7 and Neural Tube Defects
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with AGP7 and Blood
 Bone Marrow Antibodies  >3 publications with AGP7 and Bone Marrow
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