Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Protein rightarrow AGP7  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • BiP (HSPA5) Antibody
 • NR0B2 Antibody
 • H-Gly-Gly-Gly-Gly-Arg-Gly-A sp-Ser-Pro-OH Biologically Active Peptide
 • DKK1 Antibody
 • EGF-containing fibulin-like extracellular matrix protein 1 (... ELISA Kit
 • CXCR1 Antibody
 • Connexin 43 (CX43) Antibody
 • KIP1-CDKN1B Antibody
 • Abeta1-42 ELISA Kit
 • L-lactate dehydrogenase A chain (LDHA) ELISA Kit
 • ANGPT4 ELISA Kit
 • Bu-1 Secondary Antibody
 • c-AMP dependant Protein Kinase A regulatory subunit 2 alpha ... Recombinant Protein
 • OGT Peptide
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

AGP7 protein :: Proteinase 3 (PR3) Protein

Scan QR to view Datasheet Catalog #    MBS844097
Testing Data
Unit / Price
0.025 mg  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proteinase 3 (PR3) (AGP7), Protein

★Popular Item★
 Also Known As   

Proteinase 3 (PR3), Human Neutrophil

 Product Synonym Names    AGP7; C-ANCA antigen; Leukocyte proteinase 3; Neutrophil proteinase 4; P29; Wegener autoantigen
 Product Gene Name   

AGP7 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    177020
 3D Structure    ModBase 3D Structure for P24158
Section Bar
 Host    Human Neutrophils
Section Bar
 Purity/Purification    >=95% by SDS-PAGE
 Form/Format    Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl
Section Bar
 Host Note    Human Neutrophil. Prepared from whole blood shown to be non reactive for HBsAg, anti HCV, anti HBc, and negative for anti HIV 1 & 2 by FDA approved tests.
 Extinction Coefficient    1.00
 Handling    Centrifuge the vial prior to opening.
Section Bar
 Preparation and Storage    Aliquot and store at - 70C or lower. Avoid repated freezing and thawing cycles.

Shipping: Dry Ice
 Other Notes    Small volumes of AGP7 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for AGP7 protein

   Background: Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by alpha1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation.
 Product Categories/Family for AGP7 protein    Proteins and Enzymes; Native Proteins (NEW CATEGORY)Proteins and Enzymes; Proteases; Other (NEW CATEGORY)Proteins and Enzymes; Proteins and Enzymes (A-Z)
 Applications Tested/Suitable for AGP7 protein   

SDS-PAGE

Section Bar
 Testing Data of AGP7 protein    AGP7 protein Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for AGP7. It may not necessarily be applicable to this product.
 NCBI GI #    71361688
 NCBI GeneID    5657
 NCBI Accession #    NP_002768.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002777.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P24158 [Other Products]
 UniProt Secondary Accession #    P15637; P18078; Q4VB08; Q4VB09; Q6LBM7; Q6LBN2; Q9UD25; Q9UQD8 [Other Products]
 UniProt Related Accession #    P24158 [Other Products]
 Molecular Weight    29 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    myeloblastin
 NCBI Official Synonym Full Names    proteinase 3
 NCBI Official Symbol    PRTN3 [Similar Products]
 NCBI Official Synonym Symbols   
MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA
[Similar Products]
 NCBI Protein Information    myeloblastin
 UniProt Protein Name    Myeloblastin
 UniProt Synonym Protein Names   
AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen
 Protein Family    Classical arabinogalactan protein
 UniProt Gene Name    PRTN3 [Similar Products]
 UniProt Synonym Gene Names    MBN; PR-3; PR3; NP-4 [Similar Products]
 UniProt Entry Name    PRTN3_HUMAN
Section Bar
 UniProt Comments for AGP7    PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily.

Protein type: EC 3.4.21.76; Protease; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: extracellular matrix; extracellular space; plasma membrane; cytosol

Molecular Function: enzyme binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: negative regulation of phagocytosis; collagen catabolic process; positive regulation of cell proliferation; blood coagulation; proteolysis
Table BarTOPTable Bar
 Research Articles on AGP7    1. Anti-PR3 autoantibodies not detected in sera of patients with pulmonary tuberculosis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with AGP7 proteinPathways associated with AGP7 protein
 Reference Product  PubMed Publications
 MYB protein  >1 publications with AGP7 and MYB
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with AGP7 proteinOrgans/Tissues associated with AGP7 protein
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >7 publications with AGP7 and Vascular Diseases
 Granulomatosis with Polyangiitis Antibodies  >7 publications with AGP7 and Granulomatosis with Polyangiitis
 Lung Diseases Antibodies  >5 publications with AGP7 and Lung Diseases
 Neural Tube Defects Antibodies  >1 publications with AGP7 and Neural Tube Defects
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with AGP7 and Blood
 Bone Marrow Antibodies  >3 publications with AGP7 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions