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LRPAP1 protein :: RAP Protein

Scan QR to view Datasheet Catalog #    MBS135849 LRPAP1 protein
Unit / Price
0.5 mg  /  $600 +1 FREE 8GB USB
1 mg  /  $1,000 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

RAP (LRPAP1), Protein

★Popular Item★
 Also Known As   

Human RAP

 Product Gene Name   

LRPAP1 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (3505324..3534224, complement). Location: 4p16.3
 OMIM    104225
 3D Structure    ModBase 3D Structure for P30533
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 Host    E. coli
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 Purity/Purification    >90% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    2.5 mg/ml (lot specific)
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 Buffer    0.1M Tris-HCl; 0.1M NaCl; pH 7.4
 Extinction Coefficient    0.93
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 3 years from delivery
 Other Notes    Small volumes of LRPAP1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LRPAP1 protein

   Produced recombinantly in E. Coli. Suitable to block receptor function in uptake assays. Contains endotoxin which might trigger signaling events.
 Product Categories/Family for LRPAP1 protein    Receptor Associated Protein (RAP); Human RAP
NCBI/Uniprot data below describe general gene information for LRPAP1. It may not necessarily be applicable to this product.
 NCBI GI #    4505021
 NCBI GeneID    4043
 NCBI Accession #    NP_002328.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002337.3 [Other Products]
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 UniProt Primary Accession #    P30533 [Other Products]
 UniProt Secondary Accession #    Q2M310; Q53HQ3; Q53HS6; D3DVR9 [Other Products]
 UniProt Related Accession #    P30533 [Other Products]
 Molecular Weight    39,000
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 NCBI Official Full Name    alpha-2-macroglobulin receptor-associated protein
 NCBI Official Synonym Full Names    low density lipoprotein receptor-related protein associated protein 1
 NCBI Official Symbol    LRPAP1 [Similar Products]
 NCBI Official Synonym Symbols   
RAP; MRAP; A2RAP; HBP44; A2MRAP
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
 UniProt Protein Name    Alpha-2-macroglobulin receptor-associated protein
 UniProt Synonym Protein Names   
Low density lipoprotein receptor-related protein-associated protein 1
 Protein Family    Rapid alkalinization factor
 UniProt Gene Name    LRPAP1 [Similar Products]
 UniProt Synonym Gene Names    A2MRAP; Alpha-2-MRAP; RAP [Similar Products]
 UniProt Entry Name    AMRP_HUMAN
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 NCBI Summary for LRPAP1    This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for LRPAP1    LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cell surface; endoplasmic reticulum; integral to membrane; plasma membrane; extracellular region; vesicle

Molecular Function: heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity

Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding

Disease: Myopia 23, Autosomal Recessive
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 Research Articles on LRPAP1    1. LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LRPAP1 proteinPathways associated with LRPAP1 protein
 Reference Product  PubMed Publications
 LDLR protein  >3 publications with LRPAP1 and LDLR
 LRP2 protein  >2 publications with LRPAP1 and LRP2
 LRP1 protein  >2 publications with LRPAP1 and LRP1
 VLDLR protein  >1 publications with LRPAP1 and VLDLR
 RTN4 protein  >1 publications with LRPAP1 and RTN4
 LRP8 protein  >1 publications with LRPAP1 and LRP8
 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram
Diseases associated with LRPAP1 proteinOrgans/Tissues associated with LRPAP1 protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6 publications with LRPAP1 and Cardiovascular Diseases
 Brain Diseases Antibodies  >6 publications with LRPAP1 and Brain Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with LRPAP1 and Neurobehavioral Manifestations
 Neoplasms Antibodies  >2 publications with LRPAP1 and Neoplasms
 Atherosclerosis Antibodies  >2 publications with LRPAP1 and Atherosclerosis
 Drug Toxicity Antibodies  >2 publications with LRPAP1 and Drug Toxicity
 Weight Loss Antibodies  >1 publications with LRPAP1 and Weight Loss
 Cognition Disorders Antibodies  >1 publications with LRPAP1 and Cognition Disorders
 Prenatal Injuries Antibodies  >1 publications with LRPAP1 and Prenatal Injuries
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with LRPAP1 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with LRPAP1 and Blood
 Liver Antibodies  >3 publications with LRPAP1 and Liver
 Brain Antibodies  >3 publications with LRPAP1 and Brain
 Vascular Antibodies  >2 publications with LRPAP1 and Vascular
 Heart Antibodies  >2 publications with LRPAP1 and Heart
 Kidney Antibodies  >2 publications with LRPAP1 and Kidney
 Spleen Antibodies  >1 publications with LRPAP1 and Spleen
 Bladder Antibodies  >1 publications with LRPAP1 and Bladder
 Ovary Antibodies  >1 publications with LRPAP1 and Ovary
 Nerve Antibodies  >1 publications with LRPAP1 and Nerve
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