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SAP protein :: Serum Amyloid P Protein

Scan QR to view Datasheet Catalog #    MBS173186 SAP protein
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 Product Name   

Serum Amyloid P (SAP), Protein

★Popular Item★
 Also Known As   

Serum Amyloid P (SAP), Human

 Product Synonym Names    Serum Amyloid P (SAP)
 Product Gene Name   

SAP protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104770
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 Form/Format    Liquid
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 Source    Human Serum
 UNSPSC Code    51131907
 Recertification    2 years
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 Preparation and Storage    2-8 degree C
 Other Notes    Small volumes of SAP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SAP protein

   Custom preparations, technical support, bulk quantities and aliquoting available.

Human Serum Amyloid P is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. SAP has a pentagonal structure and modulates immunologic responses in man, inhibits elastase and has been suggested as an indicator of liver disease and has 51% sequence homology with C-reactive protein (CRP).
 Product Categories/Family for SAP protein    Proteins; Antigens; Standards/controls; Native Proteins; Serum Amyloid P (sap)
NCBI/Uniprot data below describe general gene information for SAP. It may not necessarily be applicable to this product.
 NCBI GI #    4502133
 NCBI GeneID    325
 NCBI Accession #    NP_001630.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001639.3 [Other Products]
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 UniProt Related Accession #    P02743 [Other Products]
 Molecular Weight    250 kDa
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 NCBI Official Full Name    serum amyloid P-component
 NCBI Official Synonym Full Names    amyloid P component, serum
 NCBI Official Symbol    APCS [Similar Products]
 NCBI Official Synonym Symbols   
SAP; PTX2; HEL-S-92n
[Similar Products]
 NCBI Protein Information    serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n
 UniProt Protein Name    Serum amyloid P-component
 UniProt Synonym Protein Names   
9.5S alpha-1-glycoproteinSerum amyloid P-component(1-203)
 Protein Family    S-layer protein
 UniProt Gene Name    APCS [Similar Products]
 UniProt Synonym Gene Names    PTX2; SAP [Similar Products]
 UniProt Entry Name    SAMP_HUMAN
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 NCBI Summary for SAP    The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
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 UniProt Comments for SAP    APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.

Protein type: Secreted; Secreted, signal peptide; Chaperone

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function: complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; acute-phase response; negative regulation of acute inflammatory response; innate immune response; chaperone-mediated protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction
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 Research Articles on SAP    1. plasma protein serum amyloid P binds to FcgammaRI on monocytes to inhibit fibrocyte differentiation, and binds to FcgammaRIIa on neutrophils to reduce neutrophil adhesion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SAP proteinPathways associated with SAP protein
 Reference Product  PubMed Publications
 GSN protein  >2 publications with SAP and GSN
 FCGR2A protein  >2 publications with SAP and FCGR2A
 TTR protein  >2 publications with SAP and TTR
 FGA protein  >1 publications with SAP and FGA
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with SAP proteinOrgans/Tissues associated with SAP protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1812 publications with SAP and Cardiovascular Diseases
 Heart Diseases Antibodies  >1767 publications with SAP and Heart Diseases
 Immune System Diseases Antibodies  >976 publications with SAP and Immune System Diseases
 Inflammation Antibodies  >495 publications with SAP and Inflammation
 Disease Models, Animal Antibodies  >484 publications with SAP and Disease Models, Animal
 Necrosis Antibodies  >275 publications with SAP and Necrosis
 Brain Diseases Antibodies  >212 publications with SAP and Brain Diseases
 Congenital Abnormalities Antibodies  >183 publications with SAP and Congenital Abnormalities
 Heart Failure Antibodies  >155 publications with SAP and Heart Failure
 Lung Diseases Antibodies  >147 publications with SAP and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >512 publications with SAP and Bone
 Lung Antibodies  >234 publications with SAP and Lung
 Liver Antibodies  >171 publications with SAP and Liver
 Muscle Antibodies  >117 publications with SAP and Muscle
 Pancreas Antibodies  >66 publications with SAP and Pancreas
 Uncharacterized Tissue Antibodies  >2 publications with SAP and Uncharacterized Tissue
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