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F3 protein :: Thromboplastin Protein

Scan QR to view Datasheet Catalog #    MBS173248 F3 protein
Unit / Price
50000 Units  /  $250 +1 FREE 8GB USB
500000 Units  /  $710 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thromboplastin (F3), Protein

★Popular Item★
 Also Known As   

Thromboplastin, Bovine Lung

 Product Synonym Names    Thromboplastin, Bovine Lung
 Product Gene Name   

F3 protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    134390
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 Purity/Purification    Purified
 Form/Format    Lyophilized
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 Source    Bovine Lung
 Moisture    < 5.0% (Karl Fischer)
 Specific Activity    >12,000 U/mg protein
 Reconstitution    0.9% sodium chloride
 Recertification    1 year
 pH    6.5 - 7.5
 Moisture Content    < 5.0% (Karl Fischer)
 Additional Info    All bovine material is collected from USDA approved facilities.
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of F3 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for F3 protein

   Custom preparations, technical support, bulk quantities and aliquoting available.

According to published literature thromboplastin substance necessary to the coagulant activity of tissue extracts; also has been referred to as the direct activator of prothrombin and as a substance from plasma, platelets, and tissues that initiates thromboplastic activity in blood coagulation.

A substance in blood and tissues which, in the presence of ionized calcium, aids in the conversion of prothrombin to thrombin. Extrinsic and intrinsic thromboplastin are formed as the result of the interaction of different clotting factors; the factors that combine to form extrinsic thromboplastin are not all derived from intravascular sources, whereas those that form intrinsic thromboplastin are.
 Product Categories/Family for F3 protein    Proteins; Antigens; Standards/controls; Native Proteins; Thromboplastin
NCBI/Uniprot data below describe general gene information for F3. It may not necessarily be applicable to this product.
 NCBI GI #    512466
 NCBI GeneID    2152
 NCBI Accession #    CAA01438.1 [Other Products]
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 UniProt Secondary Accession #    Q6FHG2; Q86WH4; D3DT47 [Other Products]
 UniProt Related Accession #    P13726 [Other Products]
 Molecular Weight    27,145 Da [Similar Products]
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 NCBI Official Full Name    thromboplastin
 NCBI Official Synonym Full Names    coagulation factor III (thromboplastin, tissue factor)
 NCBI Official Symbol    F3 [Similar Products]
 NCBI Official Synonym Symbols   
TF; TFA; CD142
[Similar Products]
 NCBI Protein Information    tissue factor
 UniProt Protein Name    Tissue factor
 UniProt Synonym Protein Names   
Coagulation factor III; Thromboplastin; CD_antigen: CD142
 Protein Family    Tissue factor
 UniProt Gene Name    F3 [Similar Products]
 UniProt Synonym Gene Names    TF [Similar Products]
 UniProt Entry Name    TF_HUMAN
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 NCBI Summary for F3    This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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 UniProt Comments for F3    F3: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF-alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. Lung, placenta and pancreas. Belongs to the tissue factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22-p21

Cellular Component: extracellular matrix; extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protease binding; phospholipid binding

Biological Process: caspase activation; activation of blood coagulation via clotting cascade; positive regulation of protein kinase B signaling cascade; activation of plasma proteins during acute inflammatory response; blood coagulation, extrinsic pathway; positive regulation of angiogenesis; positive regulation of positive chemotaxis; cytokine and chemokine mediated signaling pathway; positive regulation of endothelial cell proliferation; blood coagulation; positive regulation of cell migration
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 Research Articles on F3    1. These studies reveal the functional contributions of residues in the C-terminal half of the tissue factor ectodomain that are implicated in interacting with phosphatidylserine headgroups.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with F3 proteinPathways associated with F3 protein
 Reference Product  PubMed Publications
 F10 protein  >19 publications with F3 and F10
 TFPI protein  >4 publications with F3 and TFPI
 IL6 protein  >3 publications with F3 and IL6
 CRP protein  >3 publications with F3 and CRP
 SIRPA protein  >1 publications with F3 and SIRPA
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway antibodies  Extrinsic Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with F3 proteinOrgans/Tissues associated with F3 protein
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >703 publications with F3 and Fibrosis
 Liver Diseases Antibodies  >690 publications with F3 and Liver Diseases
 Liver Cirrhosis Antibodies  >561 publications with F3 and Liver Cirrhosis
 Nervous System Diseases Antibodies  >325 publications with F3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >143 publications with F3 and Disease Models, Animal
 Inflammation Antibodies  >126 publications with F3 and Inflammation
 Fatty Liver Antibodies  >98 publications with F3 and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >96 publications with F3 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >77 publications with F3 and Neoplasms, Experimental
 Necrosis Antibodies  >69 publications with F3 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >683 publications with F3 and Brain
 Muscle Antibodies  >194 publications with F3 and Muscle
 Ovary Antibodies  >175 publications with F3 and Ovary
 Nerve Antibodies  >158 publications with F3 and Nerve
 Kidney Antibodies  >138 publications with F3 and Kidney
 Vascular Antibodies  >138 publications with F3 and Vascular
 Heart Antibodies  >116 publications with F3 and Heart
 Connective Tissue Antibodies  >111 publications with F3 and Connective Tissue
 Eye Antibodies  >106 publications with F3 and Eye
 Lung Antibodies  >100 publications with F3 and Lung
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