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TF protein :: Transferrin, Bovine, Iron Saturated Protein

Scan QR to view Datasheet Catalog #    MBS634766 TF protein
Unit / Price
250 mg  /  $245 +1 FREE 8GB USB
1 g  /  $365 +1 FREE 8GB USB
10 g  /  $2,800 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transferrin, Bovine, Iron Saturated (TF), Protein

★Popular Item★
 Also Known As   

Transferrin, Bovine, Iron Saturated (HOLO), USA Origin

 Product Gene Name   

TF protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (133464977..133497850). Location: 3q22.1
 OMIM    190000
 3D Structure    ModBase 3D Structure for P02787
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 Purity/Purification    Molecular Biology Grade
Purity: 100%
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 CAS Number    11096-37-0
 Country of Origin    USA
  Appearance    Reddish powder
  Iron    1403ug/g
  Moisture (KF)    3.8
 Protein    100%
  Moisture (KF)    3.8%
  Sodium    3.5 mg/g
  Chloride    0.5mg/g
  pH (3%)    7.81
  Ash    2.4%
  Endotoxin    <0.1EU/mg
  Working Concentration    5-10ug/ml
  Virus    Virus P13: Absent
fBR: Absent
BVO: Absent
Mycoplasma: Absent
BfuetonQue: Absent
Bovine Adenoviruses: Absent
Bovine Respiratory syncytial virus: Absent
Robles: Absent
Reovirus: Absent
Bovine Parvovirus: Absent
 Certificate of Origin    All raw material used in the manufacturing of Transferrin is of US origin and was manufactured in USDA-registered plants. The animals used receiveCl both ante- and post-mortem inspections under certified veterinary care and were inspected to be free of apparent infectious and contagious diseases infections and injurious parasites known to be transferable to hoofed animals, such as blue-tongue fever.

In addition, all materials were heated during processing to a temperature exceeding (65 degree C) for a period of 10 hours and subjected to a pH of 5.0 or lower for at least 3 hours. Foot and mouth disease, rinderpest, contagious bovine pleur0p.neumonia, hog cholera, swine vesticular disease and African swine fever are not known to exist in the United States. Age of bovine raw material is less than 3 year.
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 Preparation and Storage    4 degree C
 Other Notes    Small volumes of TF protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TF protein

   Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 79.5kD and a serum concentration range of 1800-2700mg/L. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in hemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions.

Isolated from fresh bovine plasma from certified USA herds and tested for adventitious viruses, bovine transferrin is an essential cellular transport protein via receptor-mediated endocytosis. Suitable for use in serum-free media and RPMI..
 Product Categories/Family for TF protein    Molecular Biology; MB-Transferrin
NCBI/Uniprot data below describe general gene information for TF. It may not necessarily be applicable to this product.
 NCBI GI #    339453
 NCBI GeneID    7018
 NCBI Accession #    AAA61140.1 [Other Products]
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 UniProt Primary Accession #    P02787 [Other Products]
 UniProt Secondary Accession #    O43890; Q1HBA5; Q9NQB8; Q9UHV0 [Other Products]
 UniProt Related Accession #    P02787 [Other Products]
 Molecular Weight    76-81kD [Similar Products]
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 NCBI Official Full Name    transferrin
 NCBI Official Synonym Full Names    transferrin
 NCBI Official Symbol    TF [Similar Products]
 NCBI Official Synonym Symbols   
TFQTL1; PRO1557; PRO2086
[Similar Products]
 NCBI Protein Information    serotransferrin; siderophilin; beta-1 metal-binding globulin
 UniProt Protein Name    Serotransferrin
 UniProt Synonym Protein Names   
Beta-1 metal-binding globulin; Siderophilin
 UniProt Gene Name    TF [Similar Products]
 UniProt Synonym Gene Names    Transferrin [Similar Products]
 UniProt Entry Name    TRFE_HUMAN
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 NCBI Summary for TF    This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]
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 UniProt Comments for TF    TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: extracellular space; cell surface; cytoplasmic membrane-bound vesicle; early endosome; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle

Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding

Biological Process: platelet activation; retinal homeostasis; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport

Disease: Atransferrinemia
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 Research Articles on TF    1. The structures of hTF observed here represent key conformers captured in the dynamic nature of the transferrin family proteins and provide a structural basis for understanding the mechanism of metal uptake and release in transferrin families.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TF proteinPathways associated with TF protein
 Reference Product  PubMed Publications
 ALB protein  >81 publications with TF and ALB
 HFE protein  >67 publications with TF and HFE
 TFR2 protein  >39 publications with TF and TFR2
 TFRC protein  >17 publications with TF and TFRC
 TTR protein  >7 publications with TF and TTR
 IGFBP3 protein  >4 publications with TF and IGFBP3
 SLC40A1 protein  >3 publications with TF and SLC40A1
 APOA1 protein  >2 publications with TF and APOA1
 Products by Pathway  Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
Diseases associated with TF proteinOrgans/Tissues associated with TF protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1693 publications with TF and Neoplasms
 Cardiovascular Diseases Antibodies  >1343 publications with TF and Cardiovascular Diseases
 Inflammation Antibodies  >721 publications with TF and Inflammation
 Nervous System Diseases Antibodies  >625 publications with TF and Nervous System Diseases
 Heart Diseases Antibodies  >532 publications with TF and Heart Diseases
 Carcinoma Antibodies  >486 publications with TF and Carcinoma
 Necrosis Antibodies  >468 publications with TF and Necrosis
 Brain Diseases Antibodies  >353 publications with TF and Brain Diseases
 Atherosclerosis Antibodies  >269 publications with TF and Atherosclerosis
 Liver Diseases Antibodies  >220 publications with TF and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4367 publications with TF and Blood
 Brain Antibodies  >872 publications with TF and Brain
 Heart Antibodies  >609 publications with TF and Heart
 Liver Antibodies  >569 publications with TF and Liver
 Muscle Antibodies  >519 publications with TF and Muscle
 Lung Antibodies  >436 publications with TF and Lung
 Kidney Antibodies  >423 publications with TF and Kidney
 Embryonic Tissue Antibodies  >366 publications with TF and Embryonic Tissue
 Skin Antibodies  >195 publications with TF and Skin
 Nerve Antibodies  >195 publications with TF and Nerve
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