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AFP purified protein :: ALPHA FETOPROTEIN Purified Protein

Scan QR to view Datasheet Catalog #    MBS230298 AFP purified protein
Unit / Price
1 mg  /  $1,220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALPHA FETOPROTEIN (AFP), Purified Protein

★Popular Item★
 Also Known As   

PURIFIED HUMAN ALPHA FETOPROTEIN

 Product Gene Name   

AFP purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104150
 3D Structure    ModBase 3D Structure for P02771
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 Purity/Purification    >95%.
 Form/Format    Purified
Purified human alpha fetoprotein - liquid
 Concentration    Total protein concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.1% Sodium Azide (NaN3)
Preparation
 Buffer Solution    TRIS buffered saline.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of AFP purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AFP purified protein

   This product is a 63 kDa protein which binds copper, nickel, fatty acids, bilirubin and serum albumin. It is expressed mostly during foetal development, existing only at very low levels in healthy adults. Alpha fetoprotein is therefore a useful marker for diseases such as hepatocellular carcinoma, testicular cancer, Downs syndrome and neural tube defects.
 Applications Tested/Suitable for AFP purified protein   

Immunoassay (IY)

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NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
 NCBI GI #    4501989
 NCBI GeneID    174
 NCBI Accession #    NP_001125.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001134.2 [Other Products]
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 UniProt Primary Accession #    P02771 [Other Products]
 UniProt Secondary Accession #    B2RBU3 [Other Products]
 UniProt Related Accession #    P02771 [Other Products]
 Molecular Weight    63kD [Similar Products]
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 NCBI Official Full Name    alpha-fetoprotein
 NCBI Official Synonym Full Names    alpha-fetoprotein
 NCBI Official Symbol    AFP [Similar Products]
 NCBI Official Synonym Symbols   
AFPD; FETA; HPAFP
[Similar Products]
 NCBI Protein Information    alpha-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin
 UniProt Protein Name    Alpha-fetoprotein
 UniProt Synonym Protein Names   
Alpha-1-fetoprotein; Alpha-fetoglobulin
 Protein Family    Alpha-fetoprotein
 UniProt Gene Name    AFP [Similar Products]
 UniProt Synonym Gene Names    HPAFP [Similar Products]
 UniProt Entry Name    FETA_HUMAN
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 NCBI Summary for AFP    This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AFP    AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cytoplasm

Molecular Function: metal ion binding

Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle

Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of
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 Research Articles on AFP    1. The prognosis of patients undergoing living donor liver transplantation for hepatocellular carcinoma strongly relies on maximum AFP or des-gamma-carboxyprothrombin values before transplantation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AFP purified proteinPathways associated with AFP purified protein
 Reference Product  PubMed Publications
 JUN purified protein  >936 publications with AFP and JUN
 GPC3 purified protein  >69 publications with AFP and GPC3
 IGFBP1 purified protein  >19 publications with AFP and IGFBP1
 FOXA1 purified protein  >12 publications with AFP and FOXA1
 TP53 purified protein  >8 publications with AFP and TP53
 FOXA3 purified protein  >3 publications with AFP and FOXA3
 AHSG purified protein  >1 publications with AFP and AHSG
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with AFP purified proteinOrgans/Tissues associated with AFP purified protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >4009 publications with AFP and Liver Diseases
 Liver Neoplasms Antibodies  >3894 publications with AFP and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3666 publications with AFP and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >1267 publications with AFP and Nervous System Diseases
 Liver Cirrhosis Antibodies  >1122 publications with AFP and Liver Cirrhosis
 Neoplasm Metastasis Antibodies  >544 publications with AFP and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >438 publications with AFP and Neoplasms, Experimental
 Liver Neoplasms, Experimental Antibodies  >374 publications with AFP and Liver Neoplasms, Experimental
 Lung Neoplasms Antibodies  >345 publications with AFP and Lung Neoplasms
 Stomach Neoplasms Antibodies  >331 publications with AFP and Stomach Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4873 publications with AFP and Liver
 Blood Antibodies  >3691 publications with AFP and Blood
 Vascular Antibodies  >587 publications with AFP and Vascular
 Lung Antibodies  >393 publications with AFP and Lung
 Brain Antibodies  >327 publications with AFP and Brain
 Embryonic Tissue Antibodies  >290 publications with AFP and Embryonic Tissue
 Muscle Antibodies  >211 publications with AFP and Muscle
 Kidney Antibodies  >175 publications with AFP and Kidney
 Placenta Antibodies  >164 publications with AFP and Placenta
 Uterus Antibodies  >101 publications with AFP and Uterus
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