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POMC purified protein :: ALPHA MELANOCYTE STIMULATING HORMONE Purified Protein

Scan QR to view Datasheet Catalog #    MBS230189 POMC purified protein
Unit / Price
0.5 mg  /  $190 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALPHA MELANOCYTE STIMULATING HORMONE (POMC), Purified Protein

★Popular Item★
 Also Known As   

SYNTHETIC ALPHA MELANOCYTE STIMULATING HORMONE

 Product Synonym Names    ALPHA MSH
 Product Gene Name   

POMC purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176830
 3D Structure    ModBase 3D Structure for P01189
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 Purity/Purification    HPLC: >95%
 Form/Format    Purified
Purified synthetic peptide - liquid
 Concentration    Total protein concentration 1 mg/ml (lot specific)
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 Preparation    Solid phase synthesis
 Product Type    Purified Protein
 Buffer Solution    Acetate salt
 Preservative Stabilizers    See Buffer Solution
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 Preparation and Storage    Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of POMC purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for POMC purified protein

   Synthetic alpha-melanocyte stimulating hormonePeptide sequence: Ac-SYSMEHFRWGKPV-NH2Alpha-MSH is a peptide hormone produced in the anterior pituitary gland involved in melanin production and deposition. It is also associated with the actions and production of proinflammatory cytokines such as TNF-a.
 Applications Tested/Suitable for POMC purified protein   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.
 NCBI GI #    4505949
 NCBI GeneID    5443
 NCBI Accession #    NP_000930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000939.2 [Other Products]
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 UniProt Primary Accession #    P01189 [Other Products]
 UniProt Secondary Accession #    P78442; Q53T23; Q9UD39; Q9UD40 [Other Products]
 UniProt Related Accession #    P01189 [Other Products]
 Molecular Weight    1665 [Similar Products]
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 NCBI Official Full Name    pro-opiomelanocortin preproprotein
 NCBI Official Synonym Full Names    proopiomelanocortin
 NCBI Official Symbol    POMC [Similar Products]
 NCBI Official Synonym Symbols   
LPH; MSH; NPP; POC; ACTH; CLIP
[Similar Products]
 NCBI Protein Information    pro-opiomelanocortin; adrenocorticotropic hormone; adrenocorticotropin; alpha-MSH; alpha-melanocyte-stimulating hormone; beta-LPH; beta-MSH; beta-endorphin; beta-melanocyte-stimulating hormone; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-LPH; gamma-MSH; lipotropin beta; lipotropin gamma; melanotropin alpha; melanotropin beta; melanotropin gamma; met-enkephalin; opiomelanocortin prepropeptide; pro-ACTH-endorphin; proopiomelanocortin preproprotein
 UniProt Protein Name    Pro-opiomelanocortin
 UniProt Synonym Protein Names   
Corticotropin-lipotropinCleaved into the following 11 chains:NPP; Melanotropin gammaAlternative name(s):Gamma-MSH
 Protein Family    Corticotropin
 UniProt Gene Name    POMC [Similar Products]
 UniProt Synonym Gene Names    POMC; ACTH; CLIP [Similar Products]
 UniProt Entry Name    COLI_HUMAN
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 NCBI Summary for POMC    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014]
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 UniProt Comments for POMC    POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: extracellular space; peroxisomal matrix; cytoplasm; extracellular region; peroxisome; secretory granule

Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; hormone activity; type 4 melanocortin receptor binding; receptor binding

Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; glucose homeostasis; signal transduction; cellular pigmentation

Disease: Obesity; Proopiomelanocortin Deficiency
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 Research Articles on POMC    1. Expanding upon previous observations of high POMC in ectopic ACTH syndrome, this study specifically demonstrates elevated POMC levels can identify occult ectopic tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with POMC purified proteinPathways associated with POMC purified protein
 Reference Product  PubMed Publications
 CRH purified protein  >2220 publications with POMC and CRH
 NPY purified protein  >799 publications with POMC and NPY
 MC4R purified protein  >352 publications with POMC and MC4R
 MC1R purified protein  >231 publications with POMC and MC1R
 CYP17A1 purified protein  >200 publications with POMC and CYP17A1
 MC3R purified protein  >150 publications with POMC and MC3R
 MC2R purified protein  >127 publications with POMC and MC2R
 MC5R purified protein  >90 publications with POMC and MC5R
 OPRM1 purified protein  >15 publications with POMC and OPRM1
 GIPR purified protein  >5 publications with POMC and GIPR
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
Diseases associated with POMC purified proteinOrgans/Tissues associated with POMC purified protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4202 publications with POMC and Immune System Diseases
 Cushing Syndrome Antibodies  >2895 publications with POMC and Cushing Syndrome
 Mental Disorders Antibodies  >2669 publications with POMC and Mental Disorders
 Obesity Antibodies  >1726 publications with POMC and Obesity
 Infection Antibodies  >1017 publications with POMC and Infection
 Kidney Diseases Antibodies  >1004 publications with POMC and Kidney Diseases
 Gastrointestinal Diseases Antibodies  >944 publications with POMC and Gastrointestinal Diseases
 Diabetes Mellitus Antibodies  >850 publications with POMC and Diabetes Mellitus
 Necrosis Antibodies  >675 publications with POMC and Necrosis
 Hemorrhage Antibodies  >670 publications with POMC and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18468 publications with POMC and Brain
 Pituitary Gland Antibodies  >9008 publications with POMC and Pituitary Gland
 Lung Antibodies  >989 publications with POMC and Lung
 Eye Antibodies  >617 publications with POMC and Eye
 Testis Antibodies  >554 publications with POMC and Testis
 Intestine Antibodies  >434 publications with POMC and Intestine
 Embryonic Tissue Antibodies  >392 publications with POMC and Embryonic Tissue
 Placenta Antibodies  >367 publications with POMC and Placenta
 Uterus Antibodies  >239 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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