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APOA1 purified protein :: Apolipoprotein A1 Purified Protein

Scan QR to view Datasheet Catalog #    MBS135961 APOA1 purified protein
Unit / Price
1 mg  /  $455 +1 FREE 8GB USB
2.5 mg  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Apolipoprotein A1 (APOA1), Purified Protein

★Popular Item★
 Also Known As   

Apolipoprotein A1, Human Plasma, HDL

 Product Gene Name   

APOA1 purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 604091
 3D Structure    ModBase 3D Structure for P02647
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 Host    Human Plasma
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 Purity/Purification    >95% by SDS-PAGE analysis
 Form/Format    Frozen liquid
 Concentration    2.21 mg/mL (lot specific)
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 Extinction Coefficient    1.22
 Buffer    0.01M Ammonium Bicarbonate; pH 7.4
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 Preparation and Storage    Storage: -70C ; Keep concentration greater than or equal to 1 mg/mL.
Shipping: Ships with dry ice.
Minimum Shelf life: 3 years from delivery.
 Other Notes    Small volumes of APOA1 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for APOA1 purified protein

   75percent of Apo A in HDL is Apo AI. Levels of Apo AI are inversely related to the risk of coronary heart disease. Apo AI is also thought to activate LCAT (lecithin cholesterol acyl tranferase). In normal plasma, Apo AI levels range from 90-130 mg per 100 ml. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE.
 Product Categories/Family for APOA1 purified protein    HUMAN PLASMA PROTEINS
NCBI/Uniprot data below describe general gene information for APOA1. It may not necessarily be applicable to this product.
 NCBI GI #    4557321
 NCBI GeneID    335
 NCBI Accession #    NP_000030.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000039.1 [Other Products]
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 UniProt Primary Accession #    P02647 [Other Products]
 UniProt Secondary Accession #    Q6LDN9; Q6Q785; Q9UCS8; Q9UCT8; A8K866 [Other Products]
 UniProt Related Accession #    P02647 [Other Products]
 Molecular Weight    28,000 [Similar Products]
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 NCBI Official Full Name    apolipoprotein A-I preproprotein
 NCBI Official Synonym Full Names    apolipoprotein A-I
 NCBI Official Symbol    APOA1 [Similar Products]
 NCBI Protein Information    apolipoprotein A-I; apo-AI
 UniProt Protein Name    Apolipoprotein A-I
 UniProt Synonym Protein Names   
Apolipoprotein A1Cleaved into the following 2 chains:Proapolipoprotein A-I; ProapoA-I; Truncated apolipoprotein A-IAlternative name(s):Apolipoprotein A-I(1-242)
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOA1 [Similar Products]
 UniProt Synonym Gene Names    Apo-AI; ApoA-I; ProapoA-I [Similar Products]
 UniProt Entry Name    APOA1_HUMAN
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 NCBI Summary for APOA1    This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOA1    APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family.

Protein type: Vesicle; Secreted, signal peptide; Secreted; Endoplasmic reticulum; Lipid-binding; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 11q23-q24

Cellular Component: extracellular space; chylomicron; cell surface; endocytic vesicle; endoplasmic reticulum lumen; early endosome; extracellular region; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; vesicle

Molecular Function: identical protein binding; lipase inhibitor activity; beta-amyloid binding; cholesterol binding; phosphatidylcholine binding; high-density lipoprotein binding; protein binding; enzyme binding; phospholipid transporter activity; chemorepellent activity; cholesterol transporter activity; phospholipid binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding

Biological Process: phototransduction, visible light; negative chemotaxis; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; sequestering of lipid; negative regulation of interleukin-1 beta secretion; regulation of cholesterol absorption; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; response to drug; cholesterol metabolic process; platelet activation; organ regeneration; regulation of Cdc42 protein signal transduction; adrenal gland development; positive regulation of hydrolase activity; positive regulation of Rho protein signal transduction; lipoprotein metabolic process; positive regulation of transferase activity; vitamin transport; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; lipoprotein biosynthetic process; response to estrogen stimulus; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; positive regulation of lipoprotein lipase activity; blood vessel endothelial cell migration; cellular lipid metabolic process; platelet degranulation; phospholipid efflux; retinoid metabolic process; transmembrane transport; response to nutrient; phospholipid homeostasis; integrin-mediated signaling pathway; receptor-mediated endocytosis; positive regulation of fatty acid biosynthetic process; regulation of protein amino acid phosphorylation; cholesterol transport; protein stabilization; protein amino acid oxidation; negative regulation of heterotypic cell-cell adhesion; neurite regeneration; cholesterol efflux; G-protein coupled receptor protein signaling pathway; glucocorticoid metabolic process; reverse cholesterol transport; negative regulation of inflammatory response; endothelial cell proliferation; blood coagulation

Disease: Hypoalphalipoproteinemia, Primary; Amyloidosis, Familial Visceral
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 Research Articles on APOA1    1. APOA1 polymorphism is independently related to HDL-C concentrations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APOA1 purified proteinPathways associated with APOA1 purified protein
 Reference Product  PubMed Publications
 APOB purified protein  >480 publications with APOA1 and APOB
 ABCA1 purified protein  >129 publications with APOA1 and ABCA1
 APOC3 purified protein  >69 publications with APOA1 and APOC3
 CETP purified protein  >59 publications with APOA1 and CETP
 APOA2 purified protein  >40 publications with APOA1 and APOA2
 LCAT purified protein  >39 publications with APOA1 and LCAT
 ALB purified protein  >8 publications with APOA1 and ALB
 TTR purified protein  >7 publications with APOA1 and TTR
 FGA purified protein  >2 publications with APOA1 and FGA
 Products by Pathway  Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
Diseases associated with APOA1 purified proteinOrgans/Tissues associated with APOA1 purified protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >440 publications with APOA1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >269 publications with APOA1 and Atherosclerosis
 Dyslipidemias Antibodies  >182 publications with APOA1 and Dyslipidemias
 Hyperlipidemias Antibodies  >125 publications with APOA1 and Hyperlipidemias
 Inflammation Antibodies  >107 publications with APOA1 and Inflammation
 Insulin Resistance Antibodies  >97 publications with APOA1 and Insulin Resistance
 Hypertension Antibodies  >76 publications with APOA1 and Hypertension
 Hypercholesterolemia Antibodies  >64 publications with APOA1 and Hypercholesterolemia
 Hypertriglyceridemia Antibodies  >58 publications with APOA1 and Hypertriglyceridemia
 Liver Diseases Antibodies  >50 publications with APOA1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >782 publications with APOA1 and Blood
 Liver Antibodies  >179 publications with APOA1 and Liver
 Heart Antibodies  >157 publications with APOA1 and Heart
 Brain Antibodies  >33 publications with APOA1 and Brain
 Muscle Antibodies  >33 publications with APOA1 and Muscle
 Lung Antibodies  >21 publications with APOA1 and Lung
 Ovary Antibodies  >15 publications with APOA1 and Ovary
 Intestine Antibodies  >15 publications with APOA1 and Intestine
 Pancreas Antibodies  >7 publications with APOA1 and Pancreas
 Embryonic Tissue Antibodies  >4 publications with APOA1 and Embryonic Tissue
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