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CA2 purified protein :: CARBONIC ANHYDRASE Purified Protein

Scan QR to view Datasheet Catalog #    MBS230374 CA2 purified protein
Unit / Price
250 mg  /  $685 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CARBONIC ANHYDRASE (CA2), Purified Protein

★Popular Item★
 Also Known As   

NATIVE BOVINE CARBONIC ANHYDRASE

 Product Gene Name   

CA2 purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P00921
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 Form/Format    Purified
Purified protein from bovine erythrocytes - liquid
 Concentration    Total protein concentration 200mg/ml. (lot specific)
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 Preparation    0.75g protein/g (1 unit as described above is equivalent to approximately 2000 Wilbur Anderson units [J. Biol. Chem. (1948) 176:147]
 Activity    700 U/g 1 unit hydrolyses 1 umole of p-nitrophenyl acetate per minute at pH 7.6 / 25 degree C
 Target Species    Bovine
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 Preparation and Storage    Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
 Other Notes    Small volumes of CA2 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CA2 purified protein

   Native Bovine Carbonic Anhydrase is a zinc-containing enzyme that acts as a catalyst in the conversion of carbon dioxide to bicarbonate.
 Applications Tested/Suitable for CA2 purified protein   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for CA2. It may not necessarily be applicable to this product.
 NCBI GI #    30466252
 NCBI GeneID    280740
 NCBI Accession #    NP_848667.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178572.2 [Other Products]
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 UniProt Primary Accession #    P00921 [Other Products]
 UniProt Secondary Accession #    Q3ZBJ5; Q865Y7 [Other Products]
 UniProt Related Accession #    P00921 [Other Products]
 Molecular Weight    Protein Molecular Weight: 30 kDa [Similar Products]
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 NCBI Official Full Name    carbonic anhydrase 2
 NCBI Official Synonym Full Names    carbonic anhydrase II
 NCBI Official Symbol    CA2 [Similar Products]
 NCBI Protein Information    carbonic anhydrase 2; CA-II; carbonate dehydratase II
 UniProt Protein Name    Carbonic anhydrase 2
 UniProt Synonym Protein Names   
Carbonate dehydratase II; Carbonic anhydrase II; CA-II
 Protein Family    Carbonic anhydrase
 UniProt Gene Name    CA2 [Similar Products]
 UniProt Synonym Gene Names    CA-II [Similar Products]
 UniProt Entry Name    CAH2_BOVIN
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 UniProt Comments for CA2    CA2: Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala- His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N- hydroxyurea interfers with zinc binding and inhibit activity. Belongs to the alpha-carbonic anhydrase family.

Protein type: Lyase; EC 4.2.1.1; Energy Metabolism - nitrogen

Cellular Component: cytoplasm; plasma membrane

Molecular Function: carbonate dehydratase activity; zinc ion binding

Biological Process: regulation of intracellular pH; one-carbon compound metabolic process
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 Research Articles on CA2    1. Folding analysis of the zinc protein, carbonic anhydrase 2 was performed using electrospray ionization ion mobility spectrometry coupled with collision-induced dissociation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with CA2 purified proteinDiseases associated with CA2 purified protein
 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Collecting Duct Acid Secretion Pathway antibodies  Collecting Duct Acid Secretion Pathway Diagram
 Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway antibodies  Erythrocytes Take Up Carbon Dioxide And Release Oxygen Pathway Diagram
 Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway antibodies  Erythrocytes Take Up Oxygen And Release Carbon Dioxide Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Nitrogen Metabolism Pathway antibodies  Nitrogen Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >6803 publications with CA2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >4687 publications with CA2 and Nervous System Diseases
 Heart Diseases Antibodies  >4082 publications with CA2 and Heart Diseases
 Disease Models, Animal Antibodies  >2298 publications with CA2 and Disease Models, Animal
 Hypertension Antibodies  >2295 publications with CA2 and Hypertension
 Necrosis Antibodies  >1385 publications with CA2 and Necrosis
 Inflammation Antibodies  >1384 publications with CA2 and Inflammation
 Hypertrophy Antibodies  >1214 publications with CA2 and Hypertrophy
 Kidney Diseases Antibodies  >786 publications with CA2 and Kidney Diseases
 Fibrosis Antibodies  >606 publications with CA2 and Fibrosis
Organs/Tissues associated with CA2 purified protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >30553 publications with CA2 and Muscle
 Brain Antibodies  >20318 publications with CA2 and Brain
 Reticulum Antibodies  >12503 publications with CA2 and Reticulum
 Liver Antibodies  >4927 publications with CA2 and Liver
 Kidney Antibodies  >4458 publications with CA2 and Kidney
 Intestine Antibodies  >2488 publications with CA2 and Intestine
 Lung Antibodies  >2054 publications with CA2 and Lung
 Skin Antibodies  >1108 publications with CA2 and Skin
 Uterus Antibodies  >826 publications with CA2 and Uterus
 Adipose Tissue Antibodies  >304 publications with CA2 and Adipose Tissue
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