NP_001121620.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
On SDS-PAGE a band corresponding to the Transferrin receptor dimer, molecular weight of 180 kDa, is visible along with higher polymers. On reduction with mercaptoethanol, a single band at 90 kDa is visible.
NCBI Official Full Name
transferrin receptor protein 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR [Similar Products]
NCBI Protein Information
transferrin receptor protein 1; transferrin receptor (p90, CD71)
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71Transferrin receptor protein 1, serum form; sTfR
UniProt Synonym Gene Names
UniProt Entry Name
TFR1_HUMAN
UniProt Comments for CD71
TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Protein type: Receptor, misc.; Membrane protein, integral; Cell surface
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; plasma membrane; melanosome; endosome; vesicle; external side of plasma membrane
Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding
Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; transferrin transport; positive regulation of bone resorption; regulation of cell growth; osteoclast differentiation; transmembrane transport; regulation of cell proliferation
Research Articles on CD71
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Products associated with CD71 native protein
Pathways associated with CD71 native protein
Diseases associated with CD71 native protein
Organs/Tissues associated with CD71 native protein
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