NP_034243.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Protein Molecular Weight: 6,045Da
NCBI Official Full Name
pro-epidermal growth factor
NCBI Official Synonym Full Names
epidermal growth factor
NCBI Official Synonym Symbols
NCBI Protein Information
pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF)
UniProt Protein Name
Pro-epidermal growth factor
UniProt Synonym Gene Names
UniProt Entry Name
EGF_MOUSE
UniProt Comments for EGF
EGF: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4); also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hormone; Membrane protein, integral; Ligand, receptor tyrosine kinase
Cellular Component: extracellular space; membrane; lysosomal membrane; integral to membrane; plasma membrane; intracellular
Molecular Function: protein binding; growth factor activity; calcium ion binding; epidermal growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of mitosis; activation of MAPKK activity; positive regulation of transcription, DNA-dependent; regulation of protein transport; positive regulation of MAP kinase activity; regulation of protein secretion; positive regulation of epidermal growth factor receptor activity; branching morphogenesis of a tube; positive regulation of cell proliferation; negative regulation of secretion; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of DNA binding; positive regulation of granule cell precursor proliferation; STAT protein nuclear translocation
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Pathways associated with EGF native protein
Diseases associated with EGF native protein
Organs/Tissues associated with EGF native protein
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