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GluR2 purified protein

Scan QR to view Datasheet Catalog #    MBS230154 GluR2 purified protein
Unit / Price
0.05 mg  /  $210 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GluR2, Purified Protein

★Popular Item★
 Also Known As   

SYNTHETIC HUMAN GluR2 (aa831-842)

 Product Gene Name   

GluR2 purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    INPSSSQNSQ NF
 OMIM    138247
 3D Structure    ModBase 3D Structure for P42262
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 Purity/Purification    HPLC: >90%
 Form/Format    Purified
Purified synthetic peptide - lyophilised
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 Reconstitution    Use sterile distilled water or physiological buffer. Stable at concentrations of =>2mg/ml. This product has been lyophilised by rotary evaporation. The peptide will therefore be coating the inside of the vial and will not be visible as a powder at the bottom.
 Preparation    Solid phase synthesis
    
 Buffer Solution    Acetate salt
 Target Species    Human
 Preservative Stabilisers    See Buffer solution
    
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 Preparation and Storage    Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of GluR2 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for GluR2 purified protein   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for GluR2. It may not necessarily be applicable to this product.
 NCBI GI #    74275354
 NCBI GeneID    2891
 NCBI Accession #    NP_000817.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000826.3 [Other Products]
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 UniProt Primary Accession #    P42262 [Other Products]
 UniProt Secondary Accession #    Q96FP6; A8MT92; I6L997 [Other Products]
 UniProt Related Accession #    P42262 [Other Products]
 Molecular Weight    93,775 Da
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 NCBI Official Full Name    glutamate receptor 2 isoform 1
 NCBI Official Synonym Full Names    glutamate receptor, ionotropic, AMPA 2
 NCBI Official Symbol    GRIA2 [Similar Products]
 NCBI Official Synonym Symbols   
GLUR2; GLURB; GluA2; HBGR2; GluR-K2
[Similar Products]
 NCBI Protein Information    glutamate receptor 2; AMPA-selective glutamate receptor 2; gluR-2; gluR-B
 UniProt Protein Name    Glutamate receptor 2
 UniProt Synonym Protein Names   
AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2
 UniProt Gene Name    GRIA2 [Similar Products]
 UniProt Synonym Gene Names    GLUR2; GluR-2; GluA2 [Similar Products]
 UniProt Entry Name    GRIA2_HUMAN
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 NCBI Summary for GluR2    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GluR2    GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing.

Protein type: Membrane protein, integral; Channel, calcium; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 4q32.1

Cellular Component: postsynaptic membrane; endoplasmic reticulum membrane; synaptic vesicle; integral to plasma membrane; dendrite; plasma membrane; cell junction

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; signal transduction
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 Research Articles on GluR2    1. GRIA2 is a useful marker for distinguishing solitary fibrous tumour from most mimics
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GluR2 purified proteinPathways associated with GluR2 purified protein
 Reference Product  PubMed Publications
 GRIA1 purified protein  >14 publications with GluR2 and GRIA1
 GRIA4 purified protein  >12 publications with GluR2 and GRIA4
 GRIA3 purified protein  >7 publications with GluR2 and GRIA3
 NSF purified protein  >1 publications with GluR2 and NSF
 CTNNB1 purified protein  >1 publications with GluR2 and CTNNB1
 Products by Pathway  Pathway Diagram
 Activation Of AMPA Receptors Pathway antibodies  Activation Of AMPA Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
Diseases associated with GluR2 purified proteinOrgans/Tissues associated with GluR2 purified protein
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >19 publications with GluR2 and Mental Disorders
 Nervous System Diseases Antibodies  >16 publications with GluR2 and Nervous System Diseases
 Brain Diseases Antibodies  >8 publications with GluR2 and Brain Diseases
 Central Nervous System Diseases Antibodies  >8 publications with GluR2 and Central Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >4 publications with GluR2 and Neurobehavioral Manifestations
 Depressive Disorder Antibodies  >4 publications with GluR2 and Depressive Disorder
 Pain Antibodies  >3 publications with GluR2 and Pain
 Epilepsy Antibodies  >3 publications with GluR2 and Epilepsy
 Disease Models, Animal Antibodies  >3 publications with GluR2 and Disease Models, Animal
 Memory Disorders Antibodies  >2 publications with GluR2 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with GluR2 and Brain
 Blood Antibodies  >2 publications with GluR2 and Blood
 Muscle Antibodies  >2 publications with GluR2 and Muscle
 Lung Antibodies  >2 publications with GluR2 and Lung
 Liver Antibodies  >1 publications with GluR2 and Liver
 Heart Antibodies  >1 publications with GluR2 and Heart
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