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CALCA purified protein :: KATACALCIN Purified Protein

Scan QR to view Datasheet Catalog #    MBS230172 CALCA purified protein
Unit / Price
0.1 mg  /  $210 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KATACALCIN (CALCA), Purified Protein

★Popular Item★
 Also Known As   


 Product Gene Name   

CALCA purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Asp-Met-Se r-Ser-Asp- Leu-Glu-Ar g-Asp-His- Arg-Pro-Hi s-Val-Ser- Met-Pro-Gl n-Asn-Ala- Asn
 OMIM    114130
 3D Structure    ModBase 3D Structure for P01258
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 Purity/Purification    Purity: >95%
 Form/Format    Purified
Purified synthetic peptide - liquid
 Concentration    Approximate Protein Concentration: 1.0 mg/ml (lot specific)
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 Preparation    Solid phase synthesis
 Buffer Solution    Acetate buffer
 Target Species    Human
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 Preparation and Storage    Store at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of CALCA purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CALCA purified protein

   Human Katacalcin, also known as Calcitonin precursor peptide, is a member of the calcitonin gene family. Katacalcin is a calcium-lowering hormone that can significantly lower plasma calcium levels.
 Applications Tested/Suitable for CALCA purified protein   


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NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.
 NCBI GI #    76880484
 NCBI GeneID    796
 NCBI Accession #    NP_001029124.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001033952.2 [Other Products]
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 UniProt Primary Accession #    P01258 [Other Products]
 UniProt Secondary Accession #    Q13935; Q13937; Q52LX7; B7ZL39 [Other Products]
 UniProt Related Accession #    P01258; P06881 [Other Products]
 Molecular Weight    2436.9 Da [Similar Products]
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 NCBI Official Full Name    calcitonin isoform CT preproprotein
 NCBI Official Synonym Full Names    calcitonin-related polypeptide alpha
 NCBI Official Symbol    CALCA [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    calcitonin; calcitonin gene-related peptide 1; alpha-type CGRP; calcitonin 1; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; katacalcin
 UniProt Protein Name    Calcitonin
 UniProt Synonym Protein Names   
Calcitonin carboxyl-terminal peptide; CCP; PDN-21
 Protein Family    Calcitonin
 UniProt Gene Name    CALCA [Similar Products]
 UniProt Synonym Gene Names    CALC1; CCP [Similar Products]
 UniProt Entry Name    CALC_HUMAN
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 NCBI Summary for CALCA    This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
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 UniProt Comments for CALCA    CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular space; cell soma; cytoplasm; extracellular region; terminal button; nucleus

Molecular Function: identical protein binding; protein binding; calcitonin receptor binding; hormone activity; protein complex binding; receptor binding

Biological Process: negative regulation of osteoclast differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of interleukin-1 alpha production; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure; response to pain; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; protein amino acid phosphorylation; positive regulation of interleukin-8 production; monocyte chemotaxis; leukocyte adhesion; elevation of cytosolic calcium ion concentration; cell-cell signaling; vasculature development; neuropeptide signaling pathway; negative regulation of smooth muscle contraction; regulation of blood pressure; receptor internalization; positive regulation of cAMP biosynthetic process; negative regulation of ossification; feeding behavior; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of bone resorption; positive regulation of macrophage differentiation; inflammatory response; detection of temperature stimulus involved in sensory perception of pain; negative regulation of neurological process; aging; cytosolic calcium ion homeostasis; regulation of heart rate; adenylate cyclase activation; positive regulation of ossification; regulation of systemic arterial blood pressure by neurological process; G-protein coupled receptor internalization; response to heat; endothelial cell proliferation; regulation of inflammatory response; activation of protein kinase activity; endothelial cell migration; negative regulation of transcription, DNA-dependent; embryo implantation
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 Research Articles on CALCA    1. Maternal serum CGRP and PTHrP concentrations were positively correlated with the infant's birth weights.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CALCA purified proteinPathways associated with CALCA purified protein
 Reference Product  PubMed Publications
 RAMP1 purified protein  >2 publications with CALCA and RAMP1
 POMC purified protein  >1 publications with CALCA and POMC
 IAPP purified protein  >1 publications with CALCA and IAPP
 ADM purified protein  >1 publications with CALCA and ADM
 CALCRL purified protein  >1 publications with CALCA and CALCRL
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with CALCA purified proteinOrgans/Tissues associated with CALCA purified protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with CALCA and Inflammation
 Hypertension Antibodies  >4 publications with CALCA and Hypertension
 Neurogenic Inflammation Antibodies  >4 publications with CALCA and Neurogenic Inflammation
 Migraine Disorders Antibodies  >4 publications with CALCA and Migraine Disorders
 Headache Antibodies  >4 publications with CALCA and Headache
 Pain Antibodies  >4 publications with CALCA and Pain
 Kidney Diseases Antibodies  >3 publications with CALCA and Kidney Diseases
 Edema Antibodies  >2 publications with CALCA and Edema
 Necrosis Antibodies  >1 publications with CALCA and Necrosis
 Wounds and Injuries Antibodies  >1 publications with CALCA and Wounds and Injuries
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >11 publications with CALCA and Thyroid
 Brain Antibodies  >8 publications with CALCA and Brain
 Mixed Antibodies  >1 publications with CALCA and Mixed
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