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LTF purified protein :: LACTOFERRIN Purified Protein

Scan QR to view Datasheet Catalog #    MBS230371 LTF purified protein
Unit / Price
5 mg  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LACTOFERRIN (LTF), Purified Protein

 Also Known As   

NATIVE HUMAN LACTOFERRIN

 Product Gene Name   

LTF purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    150210
 3D Structure    ModBase 3D Structure for P02788
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 Purity/Purification    ~ 90% by Biuret method
 Form/Format    Purified
Purified protein from human milk - lyophilised
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 Reconstitution    Reconstitute with 5 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Preparation
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of LTF purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LTF purified protein

   Human lactoferrin is a 78kDa globular protein found in body secretions such as milk and saliva and is a member of the transferrin family proteins. Transferrins control the level of free iron in the body, by binding and transporting iron. Lactoferrin does not appear to have a transporting function, instead it has antimicrobial activity, by keeping the levels of iron in body fluids low and thus preventing microbes from acquiring iron. Removing free iron from body fluids and inflamed areas also serve to protect against the damaging effects of free radicals. Lactoferrin is used as a therapeutic and prophylactic treatment of various illnesses, such as cancers and intestinal illnesses.
 Applications Tested/Suitable for LTF purified protein   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for LTF. It may not necessarily be applicable to this product.
 NCBI GI #    312433998
 NCBI GeneID    4057
 NCBI Accession #    NP_001186078.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199149.1 [Other Products]
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 UniProt Primary Accession #    P02788 [Other Products]
 UniProt Secondary Accession #    O00756; Q16780; Q16785; Q16786; Q16789; Q5DSM0; Q8IU92; A8K9U8; B2MV13; B7Z4X2; E7EQH5 [Other Products]
 UniProt Related Accession #    P02788 [Other Products]
 Molecular Weight    73,161 Da [Similar Products]
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 NCBI Official Full Name    lactotransferrin isoform 2
 NCBI Official Synonym Full Names    lactotransferrin
 NCBI Official Symbol    LTF [Similar Products]
 NCBI Official Synonym Symbols   
LF; HLF2; GIG12; HEL110
[Similar Products]
 NCBI Protein Information    lactotransferrin; epididymis luminal protein 110; growth-inhibiting protein 12; kaliocin-1; lactoferricin; lactoferroxin; neutrophil lactoferrin; talalactoferrin
 UniProt Protein Name    Lactotransferrin
 UniProt Synonym Protein Names   
Growth-inhibiting protein 12; TalalactoferrinCleaved into the following 5 chains:Lactoferricin-H; Lfcin-H; Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C
 Protein Family    Lactotransferrin
 UniProt Gene Name    LTF [Similar Products]
 UniProt Synonym Gene Names    GIG12; LF; Lactoferrin; Lfcin-H [Similar Products]
 UniProt Entry Name    TRFL_HUMAN
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 NCBI Summary for LTF    This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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 UniProt Comments for LTF    LTF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Belongs to the transferrin family. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted, signal peptide; EC 3.4.21.-; Protease; Secreted

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: extracellular space; specific granule; cytoplasm; extracellular region; nucleus; secretory granule

Molecular Function: heparin binding; protein serine/threonine kinase activator activity; protein binding; ferric iron binding; DNA binding; serine-type endopeptidase activity; iron ion binding

Biological Process: interaction with host; negative regulation of lipopolysaccharide-mediated signaling pathway; ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of toll-like receptor 4 signaling pathway; antifungal humoral response; proteolysis; iron ion transport; humoral immune response; regulation of cytokine production; activation of NF-kappaB transcription factor; retinal homeostasis; positive regulation of osteoblast differentiation; negative regulation of viral genome replication; innate immune response in mucosa; response to host immune response; positive regulation of osteoblast proliferation; antibacterial humoral response; regulation of tumor necrosis factor production; negative regulation of ATPase activity; negative regulation of viral reproduction; iron assimilation by chelation and transport; negative regulation of apoptosis
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 Research Articles on LTF    1. The LTF 140A/G (exon 2, Lys/Arg) polymorphism was not associated with the susceptibility to or severity of dental caries in the Czech population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with LTF purified proteinDiseases associated with LTF purified protein
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway antibodies  Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway Diagram
 Mtb Iron Assimilation By Chelation Pathway antibodies  Mtb Iron Assimilation By Chelation Pathway Diagram
 Phagosomal Maturation (early Endosomal Stage) Pathway antibodies  Phagosomal Maturation (early Endosomal Stage) Pathway Diagram
 Response Of Mtb To Phagocytosis Pathway antibodies  Response Of Mtb To Phagocytosis Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >57 publications with LTF and Nervous System Diseases
 Immune System Diseases Antibodies  >40 publications with LTF and Immune System Diseases
 Inflammation Antibodies  >27 publications with LTF and Inflammation
 Cardiovascular Diseases Antibodies  >19 publications with LTF and Cardiovascular Diseases
 Vascular Diseases Antibodies  >16 publications with LTF and Vascular Diseases
 Lung Diseases Antibodies  >15 publications with LTF and Lung Diseases
 Heart Diseases Antibodies  >9 publications with LTF and Heart Diseases
 Hypertension Antibodies  >8 publications with LTF and Hypertension
 Breast Neoplasms Antibodies  >8 publications with LTF and Breast Neoplasms
 Necrosis Antibodies  >7 publications with LTF and Necrosis
Organs/Tissues associated with LTF purified protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >125 publications with LTF and Blood
 Brain Antibodies  >86 publications with LTF and Brain
 Muscle Antibodies  >53 publications with LTF and Muscle
 Lung Antibodies  >22 publications with LTF and Lung
 Uterus Antibodies  >17 publications with LTF and Uterus
 Liver Antibodies  >15 publications with LTF and Liver
 Skin Antibodies  >15 publications with LTF and Skin
 Eye Antibodies  >14 publications with LTF and Eye
 Bone Antibodies  >13 publications with LTF and Bone
 Intestine Antibodies  >10 publications with LTF and Intestine
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