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LDLR purified protein :: LOW DENSITY LIPOPROTEIN Purified Protein

Scan QR to view Datasheet Catalog #    MBS230182 LDLR purified protein
Unit / Price
2 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

LOW DENSITY LIPOPROTEIN (LDLR), Purified Protein

★Popular Item★
 Also Known As   

NATIVE HUMAN LOW DENSITY LIPOPROTEIN (OXIDIZED)

 Product Gene Name   

LDLR purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Form/Format    Purified
Purified oxidised LDL from human plasma - liquid
 Concentration    Total protein concentration 2.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.3 mM EDTA
 Preparation    LDL is purified to homogeneity by ultra-centrifugation. Oxidised using 20 uM cupric sulphate in PBS at 37 degree C for 24 hours. Oxidation is terminated with excess EDTA. The level of oxidation is measured using TBARS (Thiobarbituric acid reactive substances) determination using a Malondialdehyde (MDA) standard. The level of oxidation is batch specific and available on request.
 Buffer Solution    Phosphate buffered saline
 Target Species    Human
 Health and Safety Information    Donor material tested and found negative for HIV1, HIV2, HIV1 antigen, HBsAg, the antibody to HTLV1, HCV, HBcAg, ALT and syphilis.
As no test can completely guarantee this material to be free of pathogens it should be handled as potentially infectious.
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 Preparation and Storage    Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted.
Shelf Life: This product is stable for approximately 4 weeks when handled aseptically and stored at 4 degree C.
 Other Notes    Small volumes of LDLR purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LDLR purified protein

   Native oxidized Human Low Density Lipoprotein is provided, purified from human plasma in liquid form. (LDL) oxidative modification is one of the major processes involved in atherosclerosis along with other degenerative disorders. Oxidised LDL is preferentially accumulated by macrophages which become so called "foam cells" within the atheromatous plaque and contributes to the accumulation of cholesterol, typical of atherosclerosis.
 Applications Tested/Suitable for LDLR purified protein   

Functional Assays (FN)

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NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.
 NCBI GI #    306411097
 NCBI Accession #    ADM85894.1 [Other Products]
 Molecular Weight    8,219 Da [Similar Products]
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 NCBI Official Full Name    low density lipoprotein, partial
 UniProt Protein Name    Low density lipoprotein
 UniProt Synonym Protein Names   
Low density lipoprotein
 Protein Family    Low-density lipoprotein receptor
 UniProt Gene Name    LDLR [Similar Products]
 UniProt Entry Name    E1B4T0_HUMAN
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 NCBI Summary for LDLR    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
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 UniProt Comments for LDLR    LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: Golgi apparatus; cell surface; membrane; lysosome; integral to plasma membrane; late endosome; early endosome; plasma membrane; coated pit; endosome membrane; receptor complex; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; protein binding; low-density lipoprotein binding; calcium ion binding; clathrin heavy chain binding; glycoprotein binding

Biological Process: receptor-mediated endocytosis; lipoprotein catabolic process; cholesterol metabolic process; phototransduction, visible light; cholesterol homeostasis; cholesterol transport; viral reproduction; cholesterol absorption; phospholipid transport; endocytosis; lipoprotein metabolic process; lipid metabolic process; retinoid metabolic process

Disease: Hypercholesterolemia, Familial
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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