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PRO-MMP-9 purified protein

Scan QR to view Datasheet Catalog #    MBS230188 PRO-MMP-9 purified protein
Unit / Price
0.005 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRO-MMP-9, Purified Protein

★Popular Item★
 Also Known As   

NATIVE HUMAN PRO-MMP-9

 Product Gene Name   

PRO-MMP-9 purified protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    120361
 3D Structure    ModBase 3D Structure for P14780
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 Purity/Purification    SDS PAGE: >95%
This preparation is free from gelatinase B dimers and from complexes of gelatinase B with TIMP-1 or lipocalin.
 Form/Format    Purified
Purified protein from human blood - liquid
 Concentration    Approximate Protein Concentration: 0.2 mg/ml (lot specific)
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 Perservative Stabilisers    0.05% Sodium Azide (NaN3)
0.05% Brij-35
 Buffer Solution    TRIS buffered saline
 Activity    350-450 mU/mg after trypsin activation. 1 U is defined as the the amount needed to hydrolyze 1 umol of the peptide, Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg per minute.
 Target Species    Human
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 Preparation and Storage    Store at -20 degree C or for long term storage at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch if stored at -70 degree C. 3 weeks at -20 degree C.
 Other Notes    Small volumes of PRO-MMP-9 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PRO-MMP-9 purified protein   

ELISA (EIA), Functional Assays (FN)

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NCBI/Uniprot data below describe general gene information for PRO-MMP-9. It may not necessarily be applicable to this product.
 NCBI GI #    74272287
 NCBI GeneID    4318
 NCBI Accession #    NP_004985.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004994.2 [Other Products]
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 UniProt Primary Accession #    P14780 [Other Products]
 UniProt Secondary Accession #    Q3LR70; Q8N725; Q9H4Z1; Q9UCJ9; Q9UCL1; Q9UDK2; B2R7V9 [Other Products]
 UniProt Related Accession #    P14780 [Other Products]
 Molecular Weight    92 kDaA singlet of 92 kDa which upon activation exhibits a relatively stable band at 84 kDa. Lower bands are observed with increased activation.
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 NCBI Official Full Name    matrix metalloproteinase-9 preproprotein
 NCBI Official Synonym Full Names    matrix metallopeptidase 9
 NCBI Official Symbol    MMP9 [Similar Products]
 NCBI Official Synonym Symbols   
GELB; CLG4B; MMP-9; MANDP2
[Similar Products]
 NCBI Protein Information    matrix metalloproteinase-9; macrophage gelatinase; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); type V collagenase
 UniProt Protein Name    Matrix metalloproteinase-9
 UniProt Synonym Protein Names   
92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB
 UniProt Gene Name    MMP9 [Similar Products]
 UniProt Synonym Gene Names    CLG4B; MMP-9; GELB [Similar Products]
 UniProt Entry Name    MMP9_HUMAN
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 NCBI Summary for PRO-MMP-9    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRO-MMP-9    MMP9: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family.

Protein type: Motility/polarity/chemotaxis; Secreted; Protease; EC 3.4.24.35; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: collagen binding; identical protein binding; protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity

Biological Process: positive regulation of keratinocyte migration; axon guidance; collagen catabolic process; extracellular matrix disassembly; ossification; extracellular matrix organization and biogenesis; macrophage differentiation; positive regulation of apoptosis; ephrin receptor signaling pathway; proteolysis; skeletal development; leukocyte migration; embryo implantation

Disease: Metaphyseal Anadysplasia 2
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 Research Articles on PRO-MMP-9    1. MMP-9 and su PAR levels might be used as a marker for disease activity and may contribute to blast cell dissemination. MMP-9 and suPAR may be target molecules in the strategy of treatment of AML.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRO-MMP-9 purified proteinPathways associated with PRO-MMP-9 purified protein
 Reference Product  PubMed Publications
 JUN purified protein  >348 publications with PRO-MMP-9 and JUN
 TIMP1 purified protein  >300 publications with PRO-MMP-9 and TIMP1
 SRC purified protein  >45 publications with PRO-MMP-9 and SRC
 THBS1 purified protein  >22 publications with PRO-MMP-9 and THBS1
 LCN2 purified protein  >22 publications with PRO-MMP-9 and LCN2
 PLAU purified protein  >12 publications with PRO-MMP-9 and PLAU
 CDH2 purified protein  >11 publications with PRO-MMP-9 and CDH2
 PLG purified protein  >8 publications with PRO-MMP-9 and PLG
 ELN purified protein  >7 publications with PRO-MMP-9 and ELN
 FOSL1 purified protein  >4 publications with PRO-MMP-9 and FOSL1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
Diseases associated with PRO-MMP-9 purified proteinOrgans/Tissues associated with PRO-MMP-9 purified protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >547 publications with PRO-MMP-9 and Inflammation
 Neoplasm Invasiveness Antibodies  >457 publications with PRO-MMP-9 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >391 publications with PRO-MMP-9 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >183 publications with PRO-MMP-9 and Breast Neoplasms
 Liver Diseases Antibodies  >157 publications with PRO-MMP-9 and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >108 publications with PRO-MMP-9 and Carcinoma, Squamous Cell
 Aortic Diseases Antibodies  >104 publications with PRO-MMP-9 and Aortic Diseases
 Aortic Aneurysm Antibodies  >100 publications with PRO-MMP-9 and Aortic Aneurysm
 Aortic Aneurysm, Abdominal Antibodies  >81 publications with PRO-MMP-9 and Aortic Aneurysm, Abdominal
 Carcinoma, Hepatocellular Antibodies  >79 publications with PRO-MMP-9 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >871 publications with PRO-MMP-9 and Blood
 Lung Antibodies  >379 publications with PRO-MMP-9 and Lung
 Bone Antibodies  >339 publications with PRO-MMP-9 and Bone
 Brain Antibodies  >288 publications with PRO-MMP-9 and Brain
 Liver Antibodies  >227 publications with PRO-MMP-9 and Liver
 Bone Marrow Antibodies  >140 publications with PRO-MMP-9 and Bone Marrow
 Connective Tissue Antibodies  >134 publications with PRO-MMP-9 and Connective Tissue
 Kidney Antibodies  >131 publications with PRO-MMP-9 and Kidney
 Lymph Node Antibodies  >131 publications with PRO-MMP-9 and Lymph Node
 Embryonic Tissue Antibodies  >116 publications with PRO-MMP-9 and Embryonic Tissue
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