NP_620268.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
41,666 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 1A
NCBI Official Synonym Full Names
2'-5' oligoadenylate synthetase 1A
NCBI Official Synonym Symbols
NCBI Protein Information
2'-5'-oligoadenylate synthase 1A
UniProt Protein Name
2'-5'-oligoadenylate synthase 1A
UniProt Synonym Gene Names
NCBI Summary for OAS1
plays a role in interferon-induced antiviral response [RGD, Feb 2006]
UniProt Comments for OAS1
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
Research Articles on OAS1
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Disclaimer
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Products associated with OAS1 rtu elisa kit
Pathways associated with OAS1 rtu elisa kit
Diseases associated with OAS1 rtu elisa kit
Organs/Tissues associated with OAS1 rtu elisa kit
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