Q10743.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
60,445 Da
NCBI Official Full Name
Disintegrin and metalloproteinase domain-containing protein 10
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 10
NCBI Official Synonym Symbols
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 10
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 10
UniProt Synonym Protein Names
Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD_antigen: CD156c
UniProt Synonym Gene Names
NCBI Summary for ADAM10
may act as a disintegrin-metalloprotease related to the reprolysin family [RGD, Feb 2006]
UniProt Comments for ADAM10
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.
Research Articles on ADAM10
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Products associated with ADAM10 rtu elisa kit
Pathways associated with ADAM10 rtu elisa kit
Organs/Tissues associated with ADAM10 rtu elisa kit
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