NP_001073280.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,289 Da
NCBI Official Full Name
protein diaphanous homolog 1 isoform 2
NCBI Official Synonym Full Names
diaphanous related formin 1
NCBI Official Synonym Symbols
DIA1; DRF1; DFNA1; LFHL1; SCBMS; hDIA1 [Similar Products]
NCBI Protein Information
protein diaphanous homolog 1
UniProt Protein Name
Protein diaphanous homolog 1
UniProt Synonym Protein Names
Diaphanous-related formin-1; DRF1
UniProt Synonym Gene Names
NCBI Summary for DIAPH1
This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DIAPH1
Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (). Has neurite outgrowth promoting activity (). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755).
Research Articles on DIAPH1
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Products associated with DIAPH1 rtu elisa kit
Pathways associated with DIAPH1 rtu elisa kit
Diseases associated with DIAPH1 rtu elisa kit
Organs/Tissues associated with DIAPH1 rtu elisa kit
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