NP_056442.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,885 Da
NCBI Official Full Name
low density lipoprotein receptor adapter protein 1
NCBI Official Synonym Full Names
low density lipoprotein receptor adaptor protein 1
NCBI Protein Information
low density lipoprotein receptor adapter protein 1
UniProt Protein Name
Low density lipoprotein receptor adapter protein 1
UniProt Synonym Protein Names
Autosomal recessive hypercholesterolemia protein
NCBI Summary for LDLRAP1
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]
UniProt Comments for LDLRAP1
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression ().
Research Articles on LDLRAP1
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Products associated with LDLRAP1 rtu elisa kit
Pathways associated with LDLRAP1 rtu elisa kit
Diseases associated with LDLRAP1 rtu elisa kit
Organs/Tissues associated with LDLRAP1 rtu elisa kit
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