NP_001288141.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
212,697 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily M member 7 isoform b
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily M member 7
NCBI Official Synonym Symbols
CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK [Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily M member 7
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 7
UniProt Synonym Protein Names
Channel-kinase 1; Long transient receptor potential channel 7; LTrpC-7; LTrpC7
UniProt Synonym Gene Names
NCBI Summary for TRPM7
This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]
UniProt Comments for TRPM7
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
Research Articles on TRPM7
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Products associated with TRPM7 rtu elisa kit
Pathways associated with TRPM7 rtu elisa kit
Diseases associated with TRPM7 rtu elisa kit
Organs/Tissues associated with TRPM7 rtu elisa kit
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