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PLAT reagent :: TPA Reagent

Scan QR to view Datasheet Catalog #    MBS635399 PLAT reagent
Unit / Price
1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TPA (PLAT), Reagent

 Also Known As   

TPA (12-O-tetradecanoylphorbol-13-acetate, Tetradecanoyl Phorbol Acetate, Phorbol-12-Myristate-13-Acetate, PMA)

 Product Gene Name   

PLAT reagent

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (42032236..42065242, complement). Location: 8p12
 3D Structure    ModBase 3D Structure for Q6LBF5
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 Purity/Purification    Highly Purified
~99%
 Form/Format    Supplied as a colorless film or foam (amorphous solid).
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 CAS Number    16561-29-8
 Molecular Formula    C36H56O8
 Solubility    Soluble in DMSO or ethanol
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 Preparation and Storage    May be stored at RT for short-term only. Long-term storage is recommended at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
 Other Notes    Small volumes of PLAT reagent vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PLAT reagent

   This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter.
 Product Categories/Family for PLAT reagent    Molecular Biology; MB-Tumor Promoters
NCBI/Uniprot data below describe general gene information for PLAT. It may not necessarily be applicable to this product.
 NCBI GI #    2285954
 NCBI GeneID    5327
 NCBI Accession #    CAA54669.1 [Other Products]
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 UniProt Primary Accession #    Q6LBF5 [Other Products]
 UniProt Related Accession #    P00750 [Other Products]
 Molecular Weight    616.83 [Similar Products]
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 NCBI Official Full Name    tPA
 NCBI Official Synonym Full Names    plasminogen activator, tissue
 NCBI Official Symbol    PLAT [Similar Products]
 NCBI Official Synonym Symbols   
TPA; T-PA
[Similar Products]
 NCBI Protein Information    tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
 UniProt Protein Name    TPA protein
 Protein Family    Tissue-type plasminogen activator
 UniProt Gene Name    tPA [Similar Products]
 UniProt Entry Name    Q6LBF5_HUMAN
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 NCBI Summary for PLAT    This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 Research Articles on PLAT    1. The combination of recombinant PA and erythropoietin increases release of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) and thereby potentially deteriorates ischemic stroke outcome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PLAT reagentOrgans/Tissues associated with PLAT reagent
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >48 publications with PLAT and Vascular
 Liver Antibodies  >45 publications with PLAT and Liver
 Brain Antibodies  >39 publications with PLAT and Brain
 Heart Antibodies  >37 publications with PLAT and Heart
 Lung Antibodies  >31 publications with PLAT and Lung
 Muscle Antibodies  >26 publications with PLAT and Muscle
 Bone Antibodies  >18 publications with PLAT and Bone
 Intestine Antibodies  >17 publications with PLAT and Intestine
 Embryonic Tissue Antibodies  >16 publications with PLAT and Embryonic Tissue
 Kidney Antibodies  >14 publications with PLAT and Kidney
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