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PIKFYVE recombinant protein :: 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1462118 PIKFYVE recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $855 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $950 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,080 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,145 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,265 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,280 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,370 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,450 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,795 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,965 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,010 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,205 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,590 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE), Recombinant Protein

 Also Known As   

Recombinant Human 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) , partial

 Product Gene Name   

PIKFYVE recombinant protein

[Similar Products]
 Product Synonym Gene Name    PIKFYVE [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-440. Partial, include the Zinc finger and DEP Domain
 Sequence    MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV NLFRFNKERA EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL QRRSSALDTR RKAEPTFGGH DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC RLCGQIFCSR CCNQEIPGKF MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDSA CSVSVLDPSE PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNTPLSTRLV SVQEDAGKSP ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRTYVRTE TTEDERKILL DSVQLKDLWK KICHHSSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI ATRAQAIAIG QAMVDGRWLD CVSHHDQLFR DEYALYRPLQ
 OMIM    121850
 3D Structure    ModBase 3D Structure for Q9Y2I7
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PIKFYVE recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PIKFYVE. It may not necessarily be applicable to this product.
 NCBI GI #    295789162
 NCBI GeneID    200576
 NCBI Accession #    NP_001171471.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001178000.1 [Other Products]
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 UniProt Primary Accession #    Q9Y2I7 [Other Products]
 UniProt Secondary Accession #    Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67 [Other Products]
 UniProt Related Accession #    Q9Y2I7 [Other Products]
 Molecular Weight    61,595 Da
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 NCBI Official Full Name    1-phosphatidylinositol 3-phosphate 5-kinase isoform 4
 NCBI Official Synonym Full Names    phosphoinositide kinase, FYVE-type zinc finger containing
 NCBI Official Symbol    PIKFYVE [Similar Products]
 NCBI Official Synonym Symbols   
CFD; FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 3-phosphate 5-kinase
 UniProt Protein Name    1-phosphatidylinositol 3-phosphate 5-kinase
 UniProt Synonym Protein Names   
FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III; PIPkin-III; Type III PIP kinase
 UniProt Gene Name    PIKFYVE [Similar Products]
 UniProt Synonym Gene Names    KIAA0981; PIP5K3; Phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III; Type III PIP kinase [Similar Products]
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 NCBI Summary for PIKFYVE    Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
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 UniProt Comments for PIKFYVE    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
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 Research Articles on PIKFYVE    1. this study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PIKFYVE recombinant proteinPathways associated with PIKFYVE recombinant protein
 Reference Product  PubMed Publications
 VAC14 recombinant protein  >16 publications with PIKFYVE and VAC14
 FIG4 recombinant protein  >13 publications with PIKFYVE and FIG4
 MTMR2 recombinant protein  >2 publications with PIKFYVE and MTMR2
 MTMR3 recombinant protein  >1 publications with PIKFYVE and MTMR3
 PIK3C3 recombinant protein  >1 publications with PIKFYVE and PIK3C3
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
Diseases associated with PIKFYVE recombinant proteinOrgans/Tissues associated with PIKFYVE recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with PIKFYVE and Nervous System Diseases
 Congenital Abnormalities Antibodies  >5 publications with PIKFYVE and Congenital Abnormalities
 Corneal Dystrophy, Fleck Antibodies  >5 publications with PIKFYVE and Corneal Dystrophy, Fleck
 Nervous System Malformations Antibodies  >4 publications with PIKFYVE and Nervous System Malformations
 Neoplasms Antibodies  >3 publications with PIKFYVE and Neoplasms
 Nerve Degeneration Antibodies  >2 publications with PIKFYVE and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >1 publications with PIKFYVE and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with PIKFYVE and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with PIKFYVE and Inflammation
 Heart Defects, Congenital Antibodies  >1 publications with PIKFYVE and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with PIKFYVE and Brain
 Intestine Antibodies  >2 publications with PIKFYVE and Intestine
 Lung Antibodies  >1 publications with PIKFYVE and Lung
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