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PLCB4 recombinant protein :: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1419426 PLCB4 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4), Recombinant Protein

 Also Known As   

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (PLCB4) , partial

 Product Gene Name   

PLCB4 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PLCB4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600810
 3D Structure    ModBase 3D Structure for Q15147
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PLCB4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PLCB4 recombinant protein

   This protein catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Two transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for PLCB4. It may not necessarily be applicable to this product.
 NCBI GI #    289547589
 NCBI GeneID    5332
 NCBI Accession #    NP_000924.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000933.3 [Other Products]
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 UniProt Primary Accession #    Q15147 [Other Products]
 UniProt Secondary Accession #    Q17R56; Q5JYS8; Q5JYS9; Q5JYT0; Q5JYT3; Q5JYT4; Q9BQW5; Q9BQW6; Q9BQW8; B7ZLK6; E2QRH8 [Other Products]
 UniProt Related Accession #    Q15147 [Other Products]
 Molecular Weight    135,845 Da
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 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a
 NCBI Official Synonym Full Names    phospholipase C beta 4
 NCBI Official Symbol    PLCB4 [Similar Products]
 NCBI Official Synonym Symbols   
ARCND2; PI-PLC
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
 UniProt Synonym Protein Names   
Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4; PLC-beta-4
 Protein Family    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
 UniProt Gene Name    PLCB4 [Similar Products]
 UniProt Synonym Gene Names    PLC-beta-4 [Similar Products]
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 NCBI Summary for PLCB4    The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
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 UniProt Comments for PLCB4    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
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 Research Articles on PLCB4    1. Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PLCB4 recombinant proteinDiseases associated with PLCB4 recombinant protein
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with PLCB4 and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >5 publications with PLCB4 and Craniofacial Abnormalities
 Ataxia Antibodies  >4 publications with PLCB4 and Ataxia
 Disease Models, Animal Antibodies  >2 publications with PLCB4 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with PLCB4 and Inflammation
 Ovarian Neoplasms Antibodies  >1 publications with PLCB4 and Ovarian Neoplasms
 Neurobehavioral Manifestations Antibodies  >1 publications with PLCB4 and Neurobehavioral Manifestations
 Liver Diseases Antibodies  >1 publications with PLCB4 and Liver Diseases
 Edema Antibodies  >1 publications with PLCB4 and Edema
 Heart Defects, Congenital Antibodies  >1 publications with PLCB4 and Heart Defects, Congenital
Organs/Tissues associated with PLCB4 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >30 publications with PLCB4 and Brain
 Nerve Antibodies  >7 publications with PLCB4 and Nerve
 Eye Antibodies  >5 publications with PLCB4 and Eye
 Ear Antibodies  >3 publications with PLCB4 and Ear
 Bone Antibodies  >2 publications with PLCB4 and Bone
 Embryonic Tissue Antibodies  >1 publications with PLCB4 and Embryonic Tissue
 Mouth Antibodies  >1 publications with PLCB4 and Mouth
 Connective Tissue Antibodies  >1 publications with PLCB4 and Connective Tissue
 Muscle Antibodies  >1 publications with PLCB4 and Muscle
 Intestine Antibodies  >1 publications with PLCB4 and Intestine
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