NP_000924.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,845 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform a
NCBI Official Synonym Full Names
phospholipase C beta 4
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-beta-4; Phospholipase C-beta-4; PLC-beta-4
UniProt Synonym Gene Names
NCBI Summary for PLCB4
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
UniProt Comments for PLCB4
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.
Research Articles on PLCB4
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Pathways associated with PLCB4 recombinant protein
Diseases associated with PLCB4 recombinant protein
Organs/Tissues associated with PLCB4 recombinant protein
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