NP_542419.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85,314 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
NCBI Official Synonym Full Names
phospholipase C, delta 4
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4
UniProt Synonym Gene Names
NCBI Summary for Plcd4
mediates signal transduction by generating two second messenger molecules, inositol 1,4,5-trisphosphate (IP) and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate (PIP) [RGD, Feb 2006]
UniProt Comments for Plcd4
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. Isoform 4 has no enzyme activity and acts as a negative regulator of phospholipases C, with a preference for PLC-delta family.
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Pathways associated with Plcd4 recombinant protein
Products by Pathway |
Pathway Diagram |
Calcium Signaling Pathway antibodies |
Calcium Signaling Pathway Diagram |
Calcium Signaling Pathway antibodies |
Calcium Signaling Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Phosphatidylinositol Signaling System Pathway antibodies |
Phosphatidylinositol Signaling System Pathway Diagram |
Phosphatidylinositol Signaling System Pathway antibodies |
Phosphatidylinositol Signaling System Pathway Diagram |
Diseases associated with Plcd4 recombinant protein
Organs/Tissues associated with Plcd4 recombinant protein
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