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PLCE1 recombinant protein :: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1340819 PLCE1 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1), Recombinant Protein

 Also Known As   

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) , partial

 Product Gene Name   

PLCE1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PLCE1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608414
 3D Structure    ModBase 3D Structure for Q9P212
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PLCE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for PLCE1. It may not necessarily be applicable to this product.
 NCBI GI #    260166694
 NCBI GeneID    51196
 NCBI Accession #    NP_001159451.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001165979.2 [Other Products]
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 UniProt Primary Accession #    Q9P212 [Other Products]
 UniProt Secondary Accession #    Q1X6H8; Q5VWL4; Q5VWL5; Q9H9X8; Q9HBX6; Q9HC53; A6NGW0; A6NLA1; A7MBN7; A8K1D7; B9EIJ6 [Other Products]
 UniProt Related Accession #    Q9P212 [Other Products]
 Molecular Weight    223,872 Da
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 NCBI Official Full Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2
 NCBI Official Synonym Full Names    phospholipase C epsilon 1
 NCBI Official Symbol    PLCE1 [Similar Products]
 NCBI Official Synonym Symbols   
PLCE; PPLC; NPHS3
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
 UniProt Protein Name    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
 UniProt Synonym Protein Names   
Pancreas-enriched phospholipase C; Phosphoinositide phospholipase C-epsilon-1; Phospholipase C-epsilon-1; PLC-epsilon-1
 Protein Family    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
 UniProt Gene Name    PLCE1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1516; PLCE; PPLC; PLC-epsilon-1 [Similar Products]
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 NCBI Summary for PLCE1    This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
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 UniProt Comments for PLCE1    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.
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 Research Articles on PLCE1    1. high expression of both PLCE1 and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PLCE1 recombinant proteinDiseases associated with PLCE1 recombinant protein
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 D-myo-inositol-5-phosphate Metabolism Pathway antibodies  D-myo-inositol-5-phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies  Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram
 Disease Name  Pubmed Publications
 Esophageal Squamous Cell Carcinoma Antibodies  >22 publications with PLCE1 and Esophageal Squamous Cell Carcinoma
 Kidney Diseases Antibodies  >21 publications with PLCE1 and Kidney Diseases
 Stomach Neoplasms Antibodies  >10 publications with PLCE1 and Stomach Neoplasms
 Adenocarcinoma Antibodies  >10 publications with PLCE1 and Adenocarcinoma
 Edema Antibodies  >3 publications with PLCE1 and Edema
 Severe Dengue Antibodies  >3 publications with PLCE1 and Severe Dengue
 Neoplasm Metastasis Antibodies  >3 publications with PLCE1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with PLCE1 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with PLCE1 and Inflammation
 Nervous System Diseases Antibodies  >1 publications with PLCE1 and Nervous System Diseases
Organs/Tissues associated with PLCE1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >14 publications with PLCE1 and Kidney
 Muscle Antibodies  >3 publications with PLCE1 and Muscle
 Liver Antibodies  >1 publications with PLCE1 and Liver
 Brain Antibodies  >1 publications with PLCE1 and Brain
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