NP_473407.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,307 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
NCBI Official Synonym Full Names
phospholipase C, zeta 1
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1
UniProt Synonym Gene Names
UniProt Comments for Plcz1
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Research Articles on Plcz1
Precautions
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Disclaimer
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Pathways associated with Plcz1 recombinant protein
Products by Pathway |
Pathway Diagram |
Calcium Signaling Pathway antibodies |
Calcium Signaling Pathway Diagram |
Calcium Signaling Pathway antibodies |
Calcium Signaling Pathway Diagram |
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol-5-phosphate Metabolism Pathway antibodies |
D-myo-inositol-5-phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Oocyte Meiosis Pathway antibodies |
Oocyte Meiosis Pathway Diagram |
Oocyte Meiosis Pathway antibodies |
Oocyte Meiosis Pathway Diagram |
Diseases associated with Plcz1 recombinant protein
Organs/Tissues associated with Plcz1 recombinant protein
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