View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List HSD11b2 recombinant protein :: 11-Beta-Hydroxysteroid Dehydrogenase Type 2 Recombinant Protein Catalog # MBS2031421 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) Unit / Price 0.01 mg / $180 +1 FREE 8GB USB 0.05 mg / $310 +1 FREE 8GB USB 0.1 mg / $470 +1 FREE 8GB USB 0.2 mg / $570 +1 FREE 8GB USB 0.5 mg / $1,075 +1 FREE 8GB USB 1 mg / $1,570 +1 FREE 8GB USB 5 mg / $3,820 +4 FREE 8GB USB 5x5 mg / $17,185 +10 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2), Recombinant Protein Popular Item Full Product Name Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 2 (HSD11b2) Product Gene Name HSD11b2 recombinant protein[Similar Products] Matching Pairs Unconjugated Antibody: HSD11b2 (MBS2026283)Immunogen: HSD11b2 (MBS2031421) Matching Pairs APC-CY7 Conjugated Antibody: HSD11b2 (MBS2076062)Immunogen: HSD11b2 (MBS2031421) Matching Pairs PE Conjugated Antibody: HSD11b2 (MBS2076063)Immunogen: HSD11b2 (MBS2031421) Show more Matching Pairs Matching Pairs APC Conjugated Antibody: HSD11b2 (MBS2076064)Immunogen: HSD11b2 (MBS2031421) Matching Pairs Cy3 Conjugated Antibody: HSD11b2 (MBS2076065)Immunogen: HSD11b2 (MBS2031421) Matching Pairs FITC Conjugated Antibody: HSD11b2 (MBS2076066)Immunogen: HSD11b2 (MBS2031421) Matching Pairs HRP Conjugated Antibody: HSD11b2 (MBS2076067)Immunogen: HSD11b2 (MBS2031421) Matching Pairs Biotin Conjugated Antibody: HSD11b2 (MBS2095914)Immunogen: HSD11b2 (MBS2031421) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP MBS2031421 Technical Datasheet Technical Datasheet PDF OMIM 218030 Host E.coli Species Reactivity Rattus norvegicus (Rat) Purity/Purification > 90% Form/Format 20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose. Concentration Original Concentration: 200ug/mL (lot specific) Source Prokaryotic expression Residues Leu58~Pro393 Tags N-terminal His Tag Subcellular Location Endoplasmic reticulum lumen Traits Freeze-dried powder Predicted isoelectric point 9.2 Usage Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. Preparation and Storage Storage:Avoid repeated freeze/thaw cycles.Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. ISO Certification Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire. Other Notes Small volumes of HSD11b2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Applications Tested/Suitable for HSD11b2 recombinant protein Positive Control; Immunogen; SDS-PAGE; Western Blot (WB). Application Notes for HSD11b2 recombinant protein (May be suitable for use in other assays to be determined by the end user.) Sequence of HSD11b2 recombinant protein Gene Sequencing (extract) of HSD11b2 recombinant protein SDS-PAGE of HSD11b2 recombinant protein TOP NCBI/Uniprot data below describe general gene information for HSD11b2. It may not necessarily be applicable to this product. NCBI GI # 1173512 NCBI GeneID 3291 UniProt Secondary Accession # Q13194; Q6P2G9; Q8N439; Q96QN8; Q9UC50; Q9UC51; Q9UCW5; Q9UCW6; Q9UCW7; A7LB28; C5HTY7[Other Products] UniProt Related Accession # P80365[Other Products] Molecular Weight Predicted Molecular Mass: 40.5kDaAccurate Molecular Mass: 41kDa as determined by SDS-PAGE reducing conditions. TOP NCBI Official Full Name 11-beta-hydroxysteroid dehydrogenase type 2 NCBI Official Synonym Full Names hydroxysteroid (11-beta) dehydrogenase 2 NCBI Official Symbol HSD11B2 [Similar Products] NCBI Official Synonym Symbols AME; AME1; HSD2; HSD11K; SDR9C3 [Similar Products] NCBI Protein Information corticosteroid 11-beta-dehydrogenase isozyme 2 UniProt Protein Name Corticosteroid 11-beta-dehydrogenase isozyme 2 UniProt Synonym Protein Names 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type II; 11-HSD type II; 11-beta-HSD type II; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; 11-beta-HSD; Short chain dehydrogenase/reductase family 9C member 3 Protein Family Corticosteroid 11-beta-dehydrogenase isozyme UniProt Gene Name HSD11B2 [Similar Products] UniProt Synonym Gene Names ; 11-DH2; 11-beta-HSD2; 11-HSD type II; 11-beta-HSD type II; 11-beta-HSD [Similar Products] UniProt Entry Name DHI2_HUMAN TOP NCBI Summary for HSD11b2 There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010] TOP UniProt Comments for HSD11b2 HSD11B2: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life and is characterized by polyuria and polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin and aldosterone levels, profound hypokalemia with metabolic alkalosis, and most often nephrocalcinosis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: Oxidoreductase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; EC 1.1.1.-Chromosomal Location of Human Ortholog: 16q22Cellular Component: endoplasmic reticulumMolecular Function: 11-beta-hydroxysteroid dehydrogenase activity; NAD binding; steroid bindingBiological Process: response to drug; response to food; response to glucocorticoid stimulus; response to hypoxia; aldosterone mediated regulation of blood volume; female pregnancy; glucocorticoid biosynthetic process; response to insulin stimulusDisease: Apparent Mineralocorticoid Excess Research Articles on HSD11b2 1. hypertensivesThe 11bHSD2 polymorphism-derived allele frequency was very low, completely absent in controls and no homozygous mutants were found TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with HSD11b2 recombinant protein Reference Product PubMed Publications CYP11B2 recombinant protein >11 publications with HSD11b2 and CYP11B2 CYP11B1 recombinant protein >9 publications with HSD11b2 and CYP11B1 HSD3B1 recombinant protein >4 publications with HSD11b2 and HSD3B1 HSD3B2 recombinant protein >3 publications with HSD11b2 and HSD3B2 NF1 recombinant protein >2 publications with HSD11b2 and NF1 AKR1D1 recombinant protein >1 publications with HSD11b2 and AKR1D1 Pathways associated with HSD11b2 recombinant protein Products by Pathway Pathway Diagram Aldosterone-regulated Sodium Reabsorption Pathway antibodies Aldosterone-regulated Sodium Reabsorption Pathway Diagram Aldosterone-regulated Sodium Reabsorption Pathway antibodies Aldosterone-regulated Sodium Reabsorption Pathway Diagram C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway antibodies C21-Steroid Hormone Biosynthesis, Progesterone => Cortisol/cortisone Pathway Diagram Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram Glucocorticoid Biosynthesis Pathway antibodies Glucocorticoid Biosynthesis Pathway Diagram Metabolism Pathway antibodies Metabolism Pathway Diagram Metabolism Of Lipids And Lipoproteins Pathway antibodies Metabolism Of Lipids And Lipoproteins Pathway Diagram Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram Prostaglandin Synthesis And Regulation Pathway antibodies Prostaglandin Synthesis And Regulation Pathway Diagram Diseases associated with HSD11b2 recombinant protein Disease Name Pubmed Publications Hypertension Antibodies >108 publications with HSD11b2 and Hypertension Cardiovascular Diseases Antibodies >67 publications with HSD11b2 and Cardiovascular Diseases Apparent mineralocorticoid excess Antibodies >53 publications with HSD11b2 and Apparent mineralocorticoid excess Mineralocorticoid Excess Syndrome, Apparent Antibodies >40 publications with HSD11b2 and Mineralocorticoid Excess Syndrome, Apparent Pregnancy Complications Antibodies >26 publications with HSD11b2 and Pregnancy Complications Kidney Diseases Antibodies >15 publications with HSD11b2 and Kidney Diseases Inflammation Antibodies >11 publications with HSD11b2 and Inflammation Renal Insufficiency Antibodies >9 publications with HSD11b2 and Renal Insufficiency Necrosis Antibodies >7 publications with HSD11b2 and Necrosis Hyperplasia Antibodies >7 publications with HSD11b2 and Hyperplasia Organs/Tissues associated with HSD11b2 recombinant protein Organ/Tissue Name Pubmed Publications Kidney Antibodies >70 publications with HSD11b2 and Kidney Placenta Antibodies >60 publications with HSD11b2 and Placenta Liver Antibodies >27 publications with HSD11b2 and Liver Brain Antibodies >15 publications with HSD11b2 and Brain Heart Antibodies >15 publications with HSD11b2 and Heart Testis Antibodies >13 publications with HSD11b2 and Testis Connective Tissue Antibodies >12 publications with HSD11b2 and Connective Tissue Lung Antibodies >7 publications with HSD11b2 and Lung Uterus Antibodies >6 publications with HSD11b2 and Uterus Thyroid Antibodies >4 publications with HSD11b2 and Thyroid TOP