NP_003396
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
30.3 kDa (266 aa), confirmed by MALDI-TOF.
NCBI Official Full Name
14-3-3 protein eta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
NCBI Official Synonym Symbols
NCBI Protein Information
14-3-3 protein eta
UniProt Protein Name
14-3-3 protein eta
UniProt Synonym Protein Names
Protein AS1
UniProt Synonym Gene Names
NCBI Summary for 14-3-3 eta
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
UniProt Comments for 14-3-3 eta
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Product References and Citations for 14-3-3 eta recombinant protein
Sato S., et al. (2006) EMBO J 25 (1):211-21; Chen J., et al. (2007), J Neurosci Res. 85 (8):1724-33;
Research Articles on 14-3-3 eta
Precautions
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Products associated with 14-3-3 eta recombinant protein
Pathways associated with 14-3-3 eta recombinant protein
Diseases associated with 14-3-3 eta recombinant protein
Organs/Tissues associated with 14-3-3 eta recombinant protein
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