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YWHAH recombinant protein :: 14-3-3 protein eta Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265389
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

14-3-3 protein eta (YWHAH), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human 14-3-3 protein eta

 Product Synonym Names    Protein AS1
 Product Gene Name   

YWHAH recombinant protein

[Similar Products]
 Product Synonym Gene Name    YWHA1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    4-246aa; Partial
 OMIM    113508
 3D Structure    ModBase 3D Structure for Q04917
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of YWHAH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for YWHAH recombinant protein

   Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
 Product Categories/Family for YWHAH recombinant protein    Signal Transduction
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 SDS-PAGE of YWHAH recombinant protein    YWHAH recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for YWHAH. It may not necessarily be applicable to this product.
 NCBI GI #    4507951
 NCBI GeneID    7533
 NCBI Accession #    NP_003396.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003405.3 [Other Products]
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 UniProt Primary Accession #    Q04917 [Other Products]
 Molecular Weight    55.3kD
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 NCBI Official Full Name    14-3-3 protein eta
 UniProt Protein Name    14-3-3 protein eta
 UniProt Synonym Protein Names   
Protein AS1
 Protein Family    14-3-3 protein
 UniProt Gene Name    YWHAH [Similar Products]
 UniProt Synonym Gene Names    YWHA1 [Similar Products]
 UniProt Entry Name    1433F_HUMAN
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 UniProt Comments for YWHAH    14-3-3 eta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Nuclear receptor co-regulator; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; mitochondrion; plasma membrane

Molecular Function: actin binding; enzyme binding; glucocorticoid receptor binding; insulin-like growth factor receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; sodium channel regulator activity

Biological Process: apoptosis; gene expression; glucocorticoid catabolic process; glucocorticoid receptor signaling pathway; intracellular protein transport; negative regulation of dendrite morphogenesis; positive regulation of transcription, DNA-dependent; programmed cell death; regulation of neuron differentiation; regulation of sodium ion transport; regulation of synaptic plasticity; small GTPase mediated signal transduction; substantia nigra development; transcription initiation from RNA polymerase II promoter
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Product References and Citations for YWHAH recombinant protein

   The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions.Swanson K.D., Dhar M.S., Joshi J.G.Biochim. Biophys. Acta 1216:145-148(1993) cDNA cloning and chromosome assignment of the gene for human brain 14-3-3 protein eta chain.Ichimura-Ohshima Y., Morii K., Ichimura T., Araki K., Takahashi Y., Isobe T., Minoshima S., Fukuyama R., Shimizu N., Kuwano R.J. Neurosci. Res. 31:600-605(1992) Leffers H., Tommerup N., Celis J.E.The effect on methamphetamine on the mRNA level for 14.3.3 eta chain in the human cultured cells.Muratake T., Hayashi S., Ichimura Y., Morii K., Kuwano R., Ichikawa T., Kumanishi T., Isobe T., Watanabe M., Kondo H.Mol. Neurobiol. 11:223-230(1995) Structural organization and chromosomal assignment of the human 14-3-3 eta chain gene (YWHAH) .Muratake T., Hayashi S., Ichikawa T., Kumanishi T., Ichimura Y., Kuwano R., Isobe T., Wang Y., Minoshima S., Shimizu N., Takahashi Y.Genomics 36:63-69(1996) A genome annotation-driven approach to cloning the human ORFeome.Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I.Genome Biol. 5:R84.1-R84.11(2004) The DNA sequence of human chromosome 22.Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.Nature 402:489-495(1999) Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.Leffers H., Madsen P., Rasmussen H.H., Honore B., Andersen A.H., Walbum E., Vandekerckhove J., Celis J.E.J. Mol. Biol. 231:982-998(1993) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.Nat. Biotechnol. 21:566-569(2003) Bienvenut W.V.Submitted (AUG-2005) to UniProtKB Regulation of glucocorticoid receptor activity by 14-3-3-dependent intracellular relocalization of the corepressor RIP140.Zilliacus J., Holter E., Wakui H., Tazawa H., Treuter E., Gustafsson J.-A.Mol. Endocrinol. 15:501-511(2001) Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.Sato S., Fujita N., Tsuruo T.J. Biol. Chem. 277:39360-39367(2002) Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization.Fujita N., Sato S., Tsuruo T.J. Biol. Chem. 278:49254-49260(2003) JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.Yoshida K., Yamaguchi T., Natsume T., Kufe D., Miki Y.Nat. Cell Biol. 7:278-285(2005) Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.Brummer T., Larance M., Herrera Abreu M.T., Lyons R.J., Timpson P., Emmerich C.H., Fleuren E.D.G., Lehrbach G.M., Schramek D., Guilhaus M., James D.E., Daly R.J.EMBO J. 27:2305-2316(2008) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014) Structural basis for protein-protein interactions in the 14-3-3 protein family.Yang X., Lee W.H., Sobott F., Papagrigoriou E., Robinson C.V., Grossmann J.G., Sundstroem M., Doyle D.A., Elkins J.M.Proc. Natl. Acad. Sci. U.S.A. 103:17237-17242(2006)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with YWHAH recombinant proteinPathways associated with YWHAH recombinant protein
 Reference Product  PubMed Publications
 YWHAE recombinant protein  >2 publications with YWHAH and YWHAE
 FOXO3 recombinant protein  >1 publications with YWHAH and FOXO3
 CDC25C recombinant protein  >1 publications with YWHAH and CDC25C
 CDC25B recombinant protein  >1 publications with YWHAH and CDC25B
 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with YWHAH recombinant proteinOrgans/Tissues associated with YWHAH recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with YWHAH and Nervous System Diseases
 Brain Diseases Antibodies  >7 publications with YWHAH and Brain Diseases
 Insulin Resistance Antibodies  >1 publications with YWHAH and Insulin Resistance
 Cell Transformation, Neoplastic Antibodies  >1 publications with YWHAH and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with YWHAH and Carcinoma, Hepatocellular
 Hypertrophy Antibodies  >1 publications with YWHAH and Hypertrophy
 Liver Diseases Antibodies  >1 publications with YWHAH and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with YWHAH and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with YWHAH and Neoplasms, Experimental
 Hyperplasia Antibodies  >1 publications with YWHAH and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with YWHAH and Brain
 Blood Antibodies  >4 publications with YWHAH and Blood
 Bone Antibodies  >3 publications with YWHAH and Bone
 Liver Antibodies  >2 publications with YWHAH and Liver
 Lymph Antibodies  >2 publications with YWHAH and Lymph
 Bone Marrow Antibodies  >2 publications with YWHAH and Bone Marrow
 Lung Antibodies  >2 publications with YWHAH and Lung
 Prostate Antibodies  >2 publications with YWHAH and Prostate
 Lymph Node Antibodies  >2 publications with YWHAH and Lymph Node
 Heart Antibodies  >1 publications with YWHAH and Heart
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