NP_001014515.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,304 Da
NCBI Official Full Name
14-3-3zeta, isoform J
NCBI Official Synonym Symbols
14-3-3; 14-3-3 zeta; 14-3-3-Leo; 14-3-3-zeta; 14-3-3leo; 14-3-3ZETA; 2G1; 4-3-3 zeta; 5.11; 549; BEST:GH05075; CG17870; D14-3-3; d14-3-3zeta; D14-3-3zeta; DmelCG17870; K; l(2)07103; l(2)46CFe; l(2)46Ee; leo; Leo; LEO; par-5; Par-5; PAR-5; PAR5 [Similar Products]
NCBI Protein Information
CG17870 gene product from transcript CG17870-RE
UniProt Protein Name
14-3-3 protein zeta
UniProt Synonym Protein Names
14-3-3-like protein; Protein Leonardo
UniProt Synonym Gene Names
UniProt Comments for 14-3-3zeta
Required in Raf-dependent cell proliferation and photoreceptor differentiation during eye development (PubMed:9159395). Acts upstream of Raf and downstream of Ras, and is essential for viability (PubMed:9159395). Acts as a negative regulator of the slo calcium channel via its interaction with slo-binding protein slob (PubMed:10230800). Inhibits yki activity by restricting its nuclear localization (PubMed:19900439). Binds to and promotes the activity of phosphoinositide 3-kinase Pi3K68D which converts phosphatidylinositol to phosphatidylinositol-3-phosphate and promotes maturation of early endosomes (PubMed:27015288).
Research Articles on 14-3-3zeta
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Pathways associated with 14-3-3zeta recombinant protein
Diseases associated with 14-3-3zeta recombinant protein
Organs/Tissues associated with 14-3-3zeta recombinant protein
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