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Hpgd recombinant protein :: 15-hydroxyprostaglandin dehydrogenase [NAD (+) ] (Hpgd) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1237622 Hpgd recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $670 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $805 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $900 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $950 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $990 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,080 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,190 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,195 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,225 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,395 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,725 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,810 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,860 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,300 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

15-hydroxyprostaglandin dehydrogenase [NAD (+) ] (Hpgd), Recombinant Protein

 Also Known As   

Recombinant Rat 15-hydroxyprostaglandin dehydrogenase [NAD (+) ] (Hpgd)

 Product Synonym Names    15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-PGDH; EC=1.1.1.141; Prostaglandin dehydrogenase 1
 Product Gene Name   

Hpgd recombinant protein

[Similar Products]
 Product Synonym Gene Name    Hpgd; Pgdh1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-266aa; Full length protein
 Sequence    MHVNGKVALV TGAAQGIGKA FTEALLLHGA KVALVDWNLE TGVKCKAALD EQFEPQKTLF IQCDVADQKQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EQTLQINLVS VISGTYLGLD YMSKQNGGEG GIIINISSIA GLMPVAQQPV YCASKHGIIG FTRSAAMAAN LMKSGVRLNV ICPGFVKTPI LESIEKEENM GQYIEYTDQI KAMMKFYGIL DPSAIANGLI NLIEDDALNG AIMKITASKG IHFQDYDLFP SFSKAP
 3D Structure    ModBase 3D Structure for O08699
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hpgd recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Hpgd recombinant protein

   This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for Hpgd. It may not necessarily be applicable to this product.
 NCBI GI #    40538858
 NCBI GeneID    79242
 NCBI Accession #    NP_077366.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_024390.2 [Other Products]
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 UniProt Primary Accession #    O08699 [Other Products]
 UniProt Secondary Accession #    Q6P687 [Other Products]
 UniProt Related Accession #    O08699 [Other Products]
 Molecular Weight    28,939 Da
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 NCBI Official Full Name    15-hydroxyprostaglandin dehydrogenase
 NCBI Official Synonym Full Names    hydroxyprostaglandin dehydrogenase 15 (NAD)
 NCBI Official Symbol    Hpgd [Similar Products]
 NCBI Protein Information    15-hydroxyprostaglandin dehydrogenase [NAD(+)]; 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; PGDH; 15-PGDH; prostaglandin dehydrogenase 1; NAD-dependent 15-hydroxyprostaglandin dehydrogenase
 UniProt Protein Name    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
 UniProt Synonym Protein Names   
Prostaglandin dehydrogenase 1
 Protein Family    15-hydroxyprostaglandin dehydrogenase
 UniProt Gene Name    Hpgd [Similar Products]
 UniProt Synonym Gene Names    Pgdh1; 15-PGDH [Similar Products]
 UniProt Entry Name    PGDH_RAT
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 NCBI Summary for Hpgd    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase [RGD, Feb 2006]
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 UniProt Comments for Hpgd    HPGD: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 1 (PHOAR1). A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Defects in HPGD are the cause of cranioosteoarthropathy (COA). A form of osterarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC); also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Oxidoreductase; EC 1.1.1.141

Cellular Component: basolateral plasma membrane; cytoplasm

Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; NAD binding; catalytic activity; prostaglandin E receptor activity

Biological Process: ovulation; transforming growth factor beta receptor signaling pathway; female pregnancy; parturition; negative regulation of cell cycle; prostaglandin metabolic process
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 Research Articles on Hpgd    1. NS398, a COX-2 specific inhibitor, protects neurons against thrombin toxicity, by inducing active PGDH. These data implicate PGDH in thrombin-mediated neuronal cell death.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Hpgd recombinant proteinDiseases associated with Hpgd recombinant protein
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Synthesis Of Lipoxins (LX) Pathway antibodies  Synthesis Of Lipoxins (LX) Pathway Diagram
 Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway antibodies  Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Osteoarthropathy, Primary Hypertrophic Antibodies  >16 publications with Hpgd and Osteoarthropathy, Primary Hypertrophic
 HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL RECESSIVE, 1 Antibodies  >16 publications with Hpgd and HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL RECESSIVE, 1
 Inflammation Antibodies  >9 publications with Hpgd and Inflammation
 Breast Neoplasms Antibodies  >3 publications with Hpgd and Breast Neoplasms
 Fetal Growth Retardation Antibodies  >2 publications with Hpgd and Fetal Growth Retardation
 Fibrosis Antibodies  >2 publications with Hpgd and Fibrosis
 Prostatic Neoplasms Antibodies  >2 publications with Hpgd and Prostatic Neoplasms
 Arthritis, Rheumatoid Antibodies  >1 publications with Hpgd and Arthritis, Rheumatoid
 Neoplasms, Experimental Antibodies  >1 publications with Hpgd and Neoplasms, Experimental
 Hypertrophy Antibodies  >1 publications with Hpgd and Hypertrophy
Organs/Tissues associated with Hpgd recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with Hpgd and Lung
 Prostate Antibodies  >4 publications with Hpgd and Prostate
 Small Intestine Antibodies  >2 publications with Hpgd and Small Intestine
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