NP_579831.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
17,822 Da
NCBI Official Full Name
selenoprotein F
NCBI Official Synonym Full Names
selenoprotein F
NCBI Official Synonym Symbols
NCBI Protein Information
selenoprotein F
UniProt Protein Name
Selenoprotein F
UniProt Synonym Protein Names
15 kDa selenoprotein
NCBI Summary for SEP15
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]
UniProt Comments for SEP15
May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum.
Research Articles on SEP15
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Products associated with SEP15 recombinant protein
Pathways associated with SEP15 recombinant protein
Diseases associated with SEP15 recombinant protein
Organs/Tissues associated with SEP15 recombinant protein
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