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HSD17b12 recombinant protein :: 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011648 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $275 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.2 mg  /  $525 +1 FREE 8GB USB
0.5 mg  /  $1,015 +1 FREE 8GB USB
1 mg  /  $1,515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12), Recombinant Protein

 Also Known As   

Recombinant 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12)

 Product Gene Name   

HSD17b12 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) (MBS2005227)
Antigen: 17-Beta-Hydroxysteroid Dehydrogenase Type 12 (HSD17b12) (MBS2011648)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -MECAPPAAG F LYWVGASTIA YLALRASYSL FRAFQVWCVG NEALVGPRLG EWAVVTGGTD GIGKAYAEEL AKRGMKIVLI SRSQDKLNQV SNNIKEKFNV ETRTIAVDFS LDDIYDKIKT GLSGLEIGVL VNNVGMSYEY PEYFLEIPDL DNTIKKLINI NVLSVCKVTR LVLPGMVERS KGVILNISSA SGMLPVPLLT IYSATKAFVD FFSQCLHEEY KSKGIFVQSV MPYLVATKLA KIQKPTLDKP SAETFVKSAI KTVGLQTRTT GYVIHSLMGS INSIMPRWMY FKIIMGFSKS LRNRYLKKRK KN
 Chromosome Location    Chromosome: 2; NC_000068.7 (94032697..94157909, complement). Location: 2 E1; 2
 3D Structure    ModBase 3D Structure for O70503
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Mus musculus (Mouse)
 Expression System    Prokaryotic expression
 Residues    Met1~Asn312 (Accession # O70503) with two N-terminal Tags, His-tag and GST-tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of HSD17b12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HSD17b12 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for HSD17b12 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of HSD17b12 recombinant protein    HSD17b12 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HSD17b12. It may not necessarily be applicable to this product.
 NCBI GI #    9789991
 NCBI GeneID    56348
 NCBI Accession #    NP_062631.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_019657.4 [Other Products]
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 UniProt Primary Accession #    O70503 [Other Products]
 UniProt Secondary Accession #    Q3TID1; Q3U7V9; Q542N3; Q8CI39 [Other Products]
 UniProt Related Accession #    O70503 [Other Products]
 Molecular Weight    61.8kDa
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 NCBI Official Full Name    estradiol 17-beta-dehydrogenase 12
 NCBI Official Synonym Full Names    hydroxysteroid (17-beta) dehydrogenase 12
 NCBI Official Symbol    Hsd17b12 [Similar Products]
 NCBI Official Synonym Symbols   
Kik1; KIK-I; AI172963; 2610510O05Rik
[Similar Products]
 NCBI Protein Information    estradiol 17-beta-dehydrogenase 12; KAR; keratonectin; keratoadhesin; 17-beta-HSD 12; steroid dehydrogenase; 3-ketoacyl-CoA reductase; 17-beta-hydroxysteroid dehydrogenase 12
 UniProt Protein Name    Estradiol 17-beta-dehydrogenase 12
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase 12; 17-beta-HSD 12; 3-ketoacyl-CoA reductase (EC:1.3.1.-); KAR; KIK-I
 Protein Family    Very-long-chain 3-oxoacyl-CoA reductase
 UniProt Gene Name    Hsd17b12 [Similar Products]
 UniProt Synonym Gene Names    Kik1; 17-beta-HSD 12; KAR [Similar Products]
 UniProt Entry Name    DHB12_MOUSE
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 UniProt Comments for HSD17b12    HSD17B12: Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: Lipid Metabolism - unsaturated fatty acid biosynthesis; EC 1.1.1.62; Membrane protein, integral; Oxidoreductase; Lipid Metabolism - androgen and estrogen; Membrane protein, multi-pass

Cellular Component: proteinaceous extracellular matrix; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: heparin binding; estradiol 17-beta-dehydrogenase activity; cis-chlorobenzene dihydrodiol dehydrogenase activity; cinnamate reductase activity; oxidoreductase activity; cis-2,3-dihydrodiol DDT dehydrogenase activity; collagen binding; 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity; trans-1,2-dihydrodiolphenanthrene dehydrogenase activity; fibronectin binding; trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity; enoyl-[acyl-carrier-protein] reductase activity; 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity

Biological Process: extracellular matrix organization and biogenesis; metabolic process; lipid metabolic process; steroid biosynthetic process
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 Research Articles on HSD17b12    1. Hsd17b12 is essential for mouse organogenesis and embryonic survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HSD17b12 recombinant proteinDiseases associated with HSD17b12 recombinant protein
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with HSD17b12 and Neoplasms
 Breast Neoplasms Antibodies  >4 publications with HSD17b12 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with HSD17b12 and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >3 publications with HSD17b12 and Prostatic Neoplasms
 Inflammation Antibodies  >2 publications with HSD17b12 and Inflammation
 Lung Diseases Antibodies  >1 publications with HSD17b12 and Lung Diseases
 Lung Neoplasms Antibodies  >1 publications with HSD17b12 and Lung Neoplasms
Organs/Tissues associated with HSD17b12 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with HSD17b12 and Blood
 Prostate Antibodies  >3 publications with HSD17b12 and Prostate
 Kidney Antibodies  >1 publications with HSD17b12 and Kidney
 Lymph Node Antibodies  >1 publications with HSD17b12 and Lymph Node
 Uncharacterized Tissue Antibodies  >1 publications with HSD17b12 and Uncharacterized Tissue
 Lung Antibodies  >1 publications with HSD17b12 and Lung
 Testis Antibodies  >1 publications with HSD17b12 and Testis
 Mammary Gland Antibodies  >1 publications with HSD17b12 and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with HSD17b12 and Embryonic Tissue
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