NP_001077394.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,620 Da
NCBI Official Full Name
inactive 2'-5'-oligoadenylate synthase 1B
NCBI Official Synonym Full Names
2'-5' oligoadenylate synthetase 1B
NCBI Official Synonym Symbols
L1; Flv; Wnv; Oas1; Oias2; Mmu-L1; Oias-2 [Similar Products]
NCBI Protein Information
inactive 2'-5'-oligoadenylate synthase 1B
UniProt Protein Name
Inactive 2'-5'-oligoadenylate synthase 1B
UniProt Synonym Protein Names
2'-5'-oligoadenylate synthase-like protein 1
UniProt Synonym Gene Names
NCBI Summary for Oas1b
This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]
UniProt Comments for Oas1b
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA (PubMed:12396720, PubMed:27663720). The full-length protein displays antiviral activity against flaviviruses such as west Nile virus (WNV) via an alternative antiviral pathway independent of RNase L (PubMed:16371364, PubMed:27663720). The truncated form of the protein lacks antiviral activity (PubMed:16371364).
Research Articles on Oas1b
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Products associated with Oas1b recombinant protein
Pathways associated with Oas1b recombinant protein
Diseases associated with Oas1b recombinant protein
Organs/Tissues associated with Oas1b recombinant protein
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