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Rnasel recombinant protein :: 2-5A-dependent ribonuclease (Rnasel) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1124427 Rnasel recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $630 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $775 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $850 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $925 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $935 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,040 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,160 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,315 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,680 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,770 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,790 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,240 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

2-5A-dependent ribonuclease (Rnasel), Recombinant Protein

 Also Known As   

Recombinant Mouse 2-5A-dependent ribonuclease (Rnasel)

 Product Gene Name   

Rnasel recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    360-590. Partial, including the Protein kinase Domain
 Sequence    LKIFIHDDYK IAGTSEGAVY LGIYDNREVA VKVFRENSPR GCKEVSCLRD CGDHSNLVAF YGREDDKGCL YVCVSLCEWT LEEFLRLPRE EPVENGEDKF AHSILLSIFE GVQKLHLHGY SHQDLQPQNI LIDSKKAVRL ADFDQSIRWM GESQMVRRDL EDLGRLVLYV VMKGEIPFET LKTQNDEVLL TMSPDEETKD LIHCLFSPGE NVKNCLVDLL GHPFFWTWEN R
 3D Structure    ModBase 3D Structure for Q05921
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Rnasel recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Rnasel. It may not necessarily be applicable to this product.
 NCBI GI #    31982957
 NCBI GeneID    24014
 NCBI Accession #    NP_036012.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_011882.2 [Other Products]
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 UniProt Primary Accession #    Q05921 [Other Products]
 UniProt Secondary Accession #    Q9ERU7 [Other Products]
 UniProt Related Accession #    Q05921 [Other Products]
 Molecular Weight    83,275 Da
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 NCBI Official Full Name    2-5A-dependent ribonuclease
 NCBI Official Synonym Full Names    ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
 NCBI Official Symbol    Rnasel [Similar Products]
 NCBI Official Synonym Symbols   
E230029I04Rik
[Similar Products]
 NCBI Protein Information    2-5A-dependent ribonuclease
 UniProt Protein Name    2-5A-dependent ribonuclease
 UniProt Synonym Protein Names   
Ribonuclease 4; Ribonuclease L; RNase L
 Protein Family    2-5A-dependent ribonuclease
 UniProt Gene Name    Rnasel [Similar Products]
 UniProt Synonym Gene Names    Rns4; 2-5A-dependent RNase; RNase L [Similar Products]
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 UniProt Comments for Rnasel    Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover (). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length ().
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 Research Articles on Rnasel    1. Pref-1 mRNA is a novel substrate of RNase-L.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Rnasel recombinant proteinDiseases associated with Rnasel recombinant protein
 Products by Pathway  Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >73 publications with Rnasel and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >73 publications with Rnasel and Prostatic Neoplasms
 Inflammation Antibodies  >15 publications with Rnasel and Inflammation
 Necrosis Antibodies  >4 publications with Rnasel and Necrosis
 Musculoskeletal Diseases Antibodies  >3 publications with Rnasel and Musculoskeletal Diseases
 Liver Diseases Antibodies  >2 publications with Rnasel and Liver Diseases
 Disease Models, Animal Antibodies  >2 publications with Rnasel and Disease Models, Animal
 Hyperplasia Antibodies  >2 publications with Rnasel and Hyperplasia
 Neoplasm Metastasis Antibodies  >2 publications with Rnasel and Neoplasm Metastasis
 Atrophy Antibodies  >1 publications with Rnasel and Atrophy
Organs/Tissues associated with Rnasel recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with Rnasel and Blood
 Lung Antibodies  >3 publications with Rnasel and Lung
 Kidney Antibodies  >3 publications with Rnasel and Kidney
 Muscle Antibodies  >2 publications with Rnasel and Muscle
 Skin Antibodies  >2 publications with Rnasel and Skin
 Brain Antibodies  >2 publications with Rnasel and Brain
 Bladder Antibodies  >1 publications with Rnasel and Bladder
 Bone Marrow Antibodies  >1 publications with Rnasel and Bone Marrow
 Lymph Node Antibodies  >1 publications with Rnasel and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with Rnasel and Embryonic Tissue
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