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ISPD recombinant protein :: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein (ISPD) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1162650 ISPD recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $870 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,090 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,160 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,295 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,340 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,380 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,465 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,825 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,980 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,020 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,230 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,610 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein (ISPD), Recombinant Protein

 Also Known As   

Recombinant Human 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein (ISPD)

 Product Gene Name   

ISPD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-451aa, full length protein
 Sequence    MEAGPPGSAR PAEPGPCLSG QRGADHTASA SLQSVAGTEP GRHPQAVAAV LPAGGCGERM GVPTPKQFCP ILERPLISYT LQALERVCWI KDIVVAVTGE NMEVMKSIIQ KYQHKRISLV EAGVTRHRSI FNGLKALAED QINSKLSKPE VVIIHDAVRP FVEEGVLLKV VTAAKEHGAA GAIRPLVSTV VSPSADGCLD YSLERARHRA SEMPQAFLFD VIYEAYQQCS DYDLEFGTEC LQLALKYCCT KAKLVEGSPD LWKVTYKRDL YAAESIIKER ISQEICVVMD TEEDNKHVGH LLEEVLKSEL NHVKVTSEAL GHAGRHLQQI ILDQCYNFVC VNVTTSDFQE TQKLLSMLEE SSLCILYPVV VVSVHFLDFK LVPPSQKMEN LMQIREFAKE VKERNILLYG LLISYPQDDQ KLQESLRQGA IIIASLIKER NSGLIGQLLI A
 OMIM    614631
 3D Structure    ModBase 3D Structure for A4D126
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ISPD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ISPD. It may not necessarily be applicable to this product.
 NCBI GI #    157671913
 NCBI GeneID    729920
 NCBI Accession #    NP_001094887.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001101417.3 [Other Products]
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 UniProt Primary Accession #    A4D126 [Other Products]
 UniProt Secondary Accession #    A8MU35; H9KVB2 [Other Products]
 UniProt Related Accession #    A4D126 [Other Products]
 Molecular Weight    44,389 Da
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 NCBI Official Full Name    D-ribitol-5-phosphate cytidylyltransferase isoform b
 NCBI Official Synonym Full Names    isoprenoid synthase domain containing
 NCBI Official Symbol    ISPD [Similar Products]
 NCBI Official Synonym Symbols   
Nip; hISPD; MDDGA7; MDDGC7; hCG_1745121
[Similar Products]
 NCBI Protein Information    D-ribitol-5-phosphate cytidylyltransferase; isoprenoid synthase domain-containing protein
 UniProt Protein Name    D-ribitol-5-phosphate cytidylyltransferase
 UniProt Synonym Protein Names   
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; Isoprenoid synthase domain-containing protein
 Protein Family    2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
 UniProt Gene Name    ISPD [Similar Products]
 UniProt Synonym Gene Names    hISPD [Similar Products]
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 NCBI Summary for ISPD    This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
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 UniProt Comments for ISPD    Cytidylyltransferase required for protein O-linked mannosylation (PubMed:26687144, PubMed:27130732, PubMed:27601598, PubMed:22522420, PubMed:22522421). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:26687144, PubMed:27130732). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:26687144, PubMed:27130732). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144).
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 Research Articles on ISPD    1. data suggest that the genetic heterogeneity of Limb Girdle Muscular Dystrophy with and without alpha-DG defects is greater than previously realized.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ISPD recombinant proteinDiseases associated with ISPD recombinant protein
 Reference Product  PubMed Publications
 IPP recombinant protein  >4 publications with ISPD and IPP
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >9 publications with ISPD and Kidney Diseases
 Muscular Diseases Antibodies  >7 publications with ISPD and Muscular Diseases
 Renal Insufficiency Antibodies  >6 publications with ISPD and Renal Insufficiency
 Congenital Abnormalities Antibodies  >6 publications with ISPD and Congenital Abnormalities
 Walker-Warburg Syndrome Antibodies  >6 publications with ISPD and Walker-Warburg Syndrome
 Nervous System Malformations Antibodies  >5 publications with ISPD and Nervous System Malformations
 Neuromuscular Diseases Antibodies  >4 publications with ISPD and Neuromuscular Diseases
 Eye Abnormalities Antibodies  >3 publications with ISPD and Eye Abnormalities
 Ocular Motility Disorders Antibodies  >2 publications with ISPD and Ocular Motility Disorders
 Hydrocephalus Antibodies  >2 publications with ISPD and Hydrocephalus
Organs/Tissues associated with ISPD recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ISPD and Brain
 Muscle Antibodies  >7 publications with ISPD and Muscle
 Blood Antibodies  >7 publications with ISPD and Blood
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