NP_001028213.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,027 Da
NCBI Official Full Name
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
NCBI Official Synonym Full Names
amino carboxymuconate semialdehyde decarboxylase
NCBI Protein Information
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
UniProt Protein Name
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
UniProt Synonym Protein Names
Picolinate carboxylase
UniProt Comments for Acmsd
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Research Articles on Acmsd
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Pathways associated with Acmsd recombinant protein
Diseases associated with Acmsd recombinant protein
Organs/Tissues associated with Acmsd recombinant protein
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