NP_414868.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
53,952 Da
NCBI Official Full Name
2-methylcitrate dehydratase
NCBI Protein Information
2-methylcitrate dehydratase
UniProt Protein Name
2-methylcitrate dehydratase
UniProt Synonym Protein Names
(2S,3S)-2-methylcitrate dehydratase
UniProt Synonym Gene Names
NCBI Summary for prpD
Crp regulon. [More information is available at EcoGene: EG13603]. The prpD gene encodes 2-methylcitrate dehydratase activity and also encodes the minor aconitase activity, aconitase C , which constitutes 5% or less of cellular activity and is observed in an acnA acnB double mutant . [More information is available at EcoCyc: G6199].
UniProt Comments for prpD
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate. It is also able to catalyze the dehydration of citrate and the hydration of cis-aconitate at a lower rate. Due to its broad substrate specificity, it seems to be responsible for the residual aconitase activity of the acnAB-null mutant.
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Products associated with prpD recombinant protein
Pathways associated with prpD recombinant protein
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