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Cyp27b1 recombinant protein :: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Cyp27b1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1076100 Cyp27b1 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,290 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,290 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,520 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,520 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,095 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,095 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,535 +3 FREE 8GB USB
1 mg (Yeast)  /  $2,535 +3 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,535 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $4,135 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Cyp27b1), Recombinant Protein

 Also Known As   

Recombinant Rat 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (Cyp27b1) , partial

 Product Gene Name   

Cyp27b1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1076100 MSDS    MSDS PDF
 Sequence Positions    1-501, Full length.
 Sequence    MTQAVKLASR VFHRVQLPSQ LGSDSVLRSL SDIPGPSTPS FLAELFCKGG LSRLHELQVH GAARYGPIWS GSFGTLRTVY VADPALVEQL LRQESHCPER CSFSSWSEHR RRHQRACGLL TADGEEWQRL RSLLAPLLLR PQAAAGYAGT LDSVVSDLVR RLRRQRGRGS GLPDLVLDVA GEFYKFGLEG IGAVLLGSRL GCLEAEVPPD TETFIEAVGS VFVSTLLTMA MPSWLHRLIP GPWARLCRDW DQMFAFAQKH VEQREGEAAV RNQGKPEEDL PTGHHLTHFL FREKVSVQSI VGNVTELLLA GVDTVSNTLS WALYELSRHP EVQSALHSEI TGAVNPGSYA HLQATALSQL PLLKAVIKEV LRLYPVVPGN SRVPDRDICV GNYVIPQDTL VSLCHYATSR DPAQFREPNS FNPARWLGEG PAPHPFASLP FGFGKRSCIG RRLAELELQM ALAQILTHFE VLPEPGALPV KPMTRTVLVP ERSIHLQFVD R
 3D Structure    ModBase 3D Structure for O35132
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cyp27b1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Cyp27b1 recombinant protein

   This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
NCBI/Uniprot data below describe general gene information for Cyp27b1. It may not necessarily be applicable to this product.
 NCBI GI #    16758598
 NCBI GeneID    114700
 NCBI Accession #    NP_446215.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053763.1 [Other Products]
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 UniProt Primary Accession #    O35132 [Other Products]
 UniProt Secondary Accession #    O35076 [Other Products]
 UniProt Related Accession #    O35132 [Other Products]
 Molecular Weight    55,369 Da
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 NCBI Official Full Name    25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
 NCBI Official Synonym Full Names    cytochrome P450, family 27, subfamily b, polypeptide 1
 NCBI Official Symbol    Cyp27b1 [Similar Products]
 NCBI Official Synonym Symbols   
Cyp40
[Similar Products]
 NCBI Protein Information    25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
 UniProt Protein Name    25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
 UniProt Synonym Protein Names   
25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; VD3 1A hydroxylase; Calcidiol 1-monooxygenase; Cytochrome P450 subfamily XXVIIB polypeptide 1; Cytochrome P450C1 alpha; Cytochrome P450VD1-alpha; Cytochrome p450 27B1
 Protein Family    25-hydroxyvitamin D-1 alpha hydroxylase
 UniProt Gene Name    Cyp27b1 [Similar Products]
 UniProt Synonym Gene Names    Cyp27b; VD3 1A hydroxylase [Similar Products]
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 NCBI Summary for Cyp27b1    cytochrome P450 enzyme that plays a role in vitamin D metabolism [RGD, Feb 2006]
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 UniProt Comments for Cyp27b1    Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) to 1-alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)3D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation.
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 Research Articles on Cyp27b1    1. Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1alpha-Hydroxylase Expression in Vascular Smooth Muscle Cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cyp27b1 recombinant proteinPathways associated with Cyp27b1 recombinant protein
 Reference Product  PubMed Publications
 Cyp24a1 recombinant protein  >425 publications with Cyp27b1 and Cyp24a1
 Pth recombinant protein  >145 publications with Cyp27b1 and Pth
 Cyp2r1 recombinant protein  >83 publications with Cyp27b1 and Cyp2r1
 Fgf23 recombinant protein  >43 publications with Cyp27b1 and Fgf23
 Trpv6 recombinant protein  >18 publications with Cyp27b1 and Trpv6
 Tlr2 recombinant protein  >12 publications with Cyp27b1 and Tlr2
 Trpv5 recombinant protein  >9 publications with Cyp27b1 and Trpv5
 Slc34a1 recombinant protein  >2 publications with Cyp27b1 and Slc34a1
 Ahr recombinant protein  >1 publications with Cyp27b1 and Ahr
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cholecalciferol Biosynthesis Pathway antibodies  Cholecalciferol Biosynthesis Pathway Diagram
 Cholecalciferol Biosynthesis Pathway antibodies  Cholecalciferol Biosynthesis Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with Cyp27b1 recombinant proteinOrgans/Tissues associated with Cyp27b1 recombinant protein
 Disease Name  Pubmed Publications
 Rickets Antibodies  >152 publications with Cyp27b1 and Rickets
 Kidney Diseases Antibodies  >134 publications with Cyp27b1 and Kidney Diseases
 Disease Models, Animal Antibodies  >57 publications with Cyp27b1 and Disease Models, Animal
 Hypercalcemia Antibodies  >53 publications with Cyp27b1 and Hypercalcemia
 Inflammation Antibodies  >50 publications with Cyp27b1 and Inflammation
 Renal Insufficiency Antibodies  >47 publications with Cyp27b1 and Renal Insufficiency
 Breast Neoplasms Antibodies  >41 publications with Cyp27b1 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >41 publications with Cyp27b1 and Prostatic Neoplasms
 Liver Diseases Antibodies  >34 publications with Cyp27b1 and Liver Diseases
 Hypertension Antibodies  >25 publications with Cyp27b1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >72 publications with Cyp27b1 and Prostate
 Embryonic Tissue Antibodies  >39 publications with Cyp27b1 and Embryonic Tissue
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