NP_005796.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79.2 kDa
NCBI Official Full Name
26S proteasome non-ATPase regulatory subunit 14
NCBI Official Synonym Full Names
proteasome 26S subunit, non-ATPase 14
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 14
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 14
UniProt Synonym Protein Names
26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1
UniProt Synonym Gene Names
NCBI Summary for PSMD14
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012]
UniProt Comments for PSMD14
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Research Articles on PSMD14
Precautions
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Products associated with PSMD14 recombinant protein
Pathways associated with PSMD14 recombinant protein
Diseases associated with PSMD14 recombinant protein
Organs/Tissues associated with PSMD14 recombinant protein
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