NP_057466.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,784 Da
NCBI Official Full Name
natural killer cell receptor 2B4 isoform 1
NCBI Official Synonym Full Names
CD244 molecule
NCBI Official Synonym Symbols
2B4; NAIL; Nmrk; NKR2B4; SLAMF4 [Similar Products]
NCBI Protein Information
natural killer cell receptor 2B4
UniProt Protein Name
Natural killer cell receptor 2B4
UniProt Synonym Protein Names
NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; SLAM family member 4; SLAMF4; Signaling lymphocytic activation molecule 4; CD_antigen: CD244
UniProt Synonym Gene Names
NCBI Summary for 2B4 / SLAMF / CD244
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for 2B4 / SLAMF / CD244
CD244: Modulate other receptor-ligand interactions to enhance leukocyte activation. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: external side of plasma membrane; plasma membrane
Molecular Function: MHC class I protein binding; protein binding
Biological Process: leukocyte migration; natural killer cell activation during immune response; signal transduction
Disease: Rheumatoid Arthritis
Research Articles on 2B4 / SLAMF / CD244
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Products associated with 2B4 / SLAMF / CD244 recombinant protein
Pathways associated with 2B4 / SLAMF / CD244 recombinant protein
Diseases associated with 2B4 / SLAMF / CD244 recombinant protein
Organs/Tissues associated with 2B4 / SLAMF / CD244 recombinant protein
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