NP_001273078.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,189 Da
NCBI Official Full Name
3'(2'),5'-bisphosphate nucleotidase 1 isoform 2
NCBI Official Synonym Full Names
3'(2'), 5'-bisphosphate nucleotidase 1
NCBI Official Synonym Symbols
NCBI Protein Information
3'(2'),5'-bisphosphate nucleotidase 1
UniProt Protein Name
3'(2'),5'-bisphosphate nucleotidase 1
UniProt Synonym Protein Names
Bisphosphate 3'-nucleotidase 1; PAP-inositol 1,4-phosphatase; PIP
UniProt Synonym Gene Names
NCBI Summary for BPNT1
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
UniProt Comments for BPNT1
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins1P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.
Research Articles on BPNT1
Precautions
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Pathways associated with BPNT1 recombinant protein
Diseases associated with BPNT1 recombinant protein
Organs/Tissues associated with BPNT1 recombinant protein
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