NP_001014165.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
39,580 Da
NCBI Official Full Name
3'-5' exoribonuclease 1
NCBI Official Synonym Full Names
exoribonuclease 1
NCBI Protein Information
3'-5' exoribonuclease 1
UniProt Protein Name
3'-5' exoribonuclease 1
UniProt Synonym Protein Names
Histone mRNA 3'-exonuclease 1
UniProt Synonym Gene Names
UniProt Comments for Eri1
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Binds with high affinity to the 3' side of the stem-loop structure and to the downstream cleavage product (DCP) of histone pre-mRNAs. Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA ().
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Diseases associated with Eri1 recombinant protein
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