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BDH2 recombinant protein :: 3-Hydroxybutyrate Dehydrogenase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145259 BDH2 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-Hydroxybutyrate Dehydrogenase (BDH2), Recombinant Protein

 Also Known As   

Recombinant Human 3-Hydroxybutyrate Dehydrogenase, Type 2

 Product Synonym Names    BDH2 Human; 3-Hydroxybutyrate Dehydrogenase, Type 2 Human Recombinant; 3-hydroxybutyrate dehydrogenase type 2; FLJ13261; PRO20933; SDR15C1; UCPA-OR; UNQ6308; dehydrogenase/reductase (SDR family) member 6; Oxidoreductase UCPA; DHRS6; R-beta-hydroxybutyrate dehydrogenase; EFA6R; EC 1.1.1.30
 Product Gene Name   

BDH2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGRLDGKVII LTAAAQGIGQ AAALAFAREG AKVIATDINE SKLQELEKYP GIQTRVLDVT KKKQIDQFAN EVERLDVLFN VAGFVHHGTV LDCEEKDWDF SMNLNVRSMY LMIKAFLPKM LAQKSGNIIN MSSVASSVKG VVNRCVYSTT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV DTPSLQERIQ ARGNPEEARN DFLKRQKTGR FATAEEIAML CVYLASDESA YVTGNPVIID GGWSL
 3D Structure    ModBase 3D Structure for Q9BUT1
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    The BDH2 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 0.1M NaCl and 10% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.
 Other Notes    Small volumes of BDH2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BDH2 recombinant protein

   Description: BDH2 produced in E Coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-245a.a.) and having a molecular mass of 28.8kDa.BDH2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: BDH2 is a member of the short-chain dehydrogenases/reductases (SDR) family. BDH2 protein has a significant part in the peripheral utilization of 3-hydroxybutyrate. BDH2 can convert high levels of circulating 3-hydroxybutyrate into acetoacetate due to cytoplasmic localization in high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters.
 Product Categories/Family for BDH2 recombinant protein    ENZYMES; Enzymes; Dehydrogenase
NCBI/Uniprot data below describe general gene information for BDH2. It may not necessarily be applicable to this product.
 NCBI GI #    66933014
 NCBI GeneID    56898
 NCBI Accession #    NP_064524.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_020139.3 [Other Products]
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 UniProt Primary Accession #    Q9BUT1 [Other Products]
 UniProt Secondary Accession #    Q503A0; Q6IA46; Q6UWD3; Q9H8S8; Q9NRX8; A8K295; B4DUF6 [Other Products]
 UniProt Related Accession #    Q9BUT1 [Other Products]
 Molecular Weight    15,626 Da
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 NCBI Official Full Name    3-hydroxybutyrate dehydrogenase type 2
 NCBI Official Synonym Full Names    3-hydroxybutyrate dehydrogenase, type 2
 NCBI Official Symbol    BDH2 [Similar Products]
 NCBI Official Synonym Symbols   
DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933
[Similar Products]
 NCBI Protein Information    3-hydroxybutyrate dehydrogenase type 2; R-beta-hydroxybutyrate dehydrogenase; dehydrogenase/reductase (SDR family) member 6; dehydrogenase/reductase SDR family member 6; oxidoreductase UCPA; short chain dehydrogenase/reductase family 15C member 1; short chain dehydrogenase/reductase family 15C, member 1
 UniProt Protein Name    3-hydroxybutyrate dehydrogenase type 2
 UniProt Synonym Protein Names   
Dehydrogenase/reductase SDR family member 6; Oxidoreductase UCPA; R-beta-hydroxybutyrate dehydrogenase; Short chain dehydrogenase/reductase family 15C member 1
 Protein Family    3-hydroxybutyrate dehydrogenase
 UniProt Gene Name    BDH2 [Similar Products]
 UniProt Synonym Gene Names    DHRS6; SDR15C1 [Similar Products]
 UniProt Entry Name    BDH2_HUMAN
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 UniProt Comments for BDH2    DHRS6: Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Carbohydrate Metabolism - butanoate; Lipid Metabolism - synthesis and degradation of ketone bodies; EC 1.1.1.30

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: mitochondrion; cytoplasm

Molecular Function: 3-hydroxybutyrate dehydrogenase activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; NAD binding

Biological Process: siderophore biosynthetic process; iron ion homeostasis; fatty acid beta-oxidation; epithelial cell differentiation; heme metabolic process
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 Research Articles on BDH2    1. BDH2 expression is an independent poor prognostic factor for CN-AML, with an anti-apoptotic role. Patients with high BDH2 expression have relatively shorter overall survival and a low complete response rate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BDH2 recombinant proteinPathways associated with BDH2 recombinant protein
 Reference Product  PubMed Publications
 BDH1 recombinant protein  >5 publications with BDH2 and BDH1
 OXCT1 recombinant protein  >1 publications with BDH2 and OXCT1
 Products by Pathway  Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Synthesis And Degradation Of Ketone Bodies Pathway antibodies  Synthesis And Degradation Of Ketone Bodies Pathway Diagram
 Synthesis And Degradation Of Ketone Bodies Pathway antibodies  Synthesis And Degradation Of Ketone Bodies Pathway Diagram
 Ketogenesis Pathway antibodies  Ketogenesis Pathway Diagram
 Ketolysis Pathway antibodies  Ketolysis Pathway Diagram
 Ketolysis Pathway antibodies  Ketolysis Pathway Diagram
Diseases associated with BDH2 recombinant proteinOrgans/Tissues associated with BDH2 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with BDH2 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with BDH2 and Inflammation
 Hypertension Antibodies  >1 publications with BDH2 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with BDH2 and Blood
 Eye Antibodies  >1 publications with BDH2 and Eye
 Spleen Antibodies  >1 publications with BDH2 and Spleen
 Adipose Tissue Antibodies  >1 publications with BDH2 and Adipose Tissue
 Liver Antibodies  >1 publications with BDH2 and Liver
 Brain Antibodies  >1 publications with BDH2 and Brain
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